94520-78-2

Basic information

• Product Name: 2-[methyl(2-methylbenzyl)amino]ethanol
• CAS NO: 94520-78-2
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.2588
• Mol File: 94520-78-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 278.9°C at 760 mmHg
• Flash Point: 97.4°C
• Density: 1.016g/cm³
• Vapor Pressure: 0.00198mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 2-[methyl(2-methylbenzyl)amino]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[methyl(2-methylbenzyl)amino]ethanol(94520-78-2)
• EPA Substance Registry System: 2-[methyl(2-methylbenzyl)amino]ethanol(94520-78-2)

Safety Data

• Hazardous Substances Data: 94520-78-2(Hazardous Substances Data)

Usage

Chemical Class

Amino alcohol

Functional Groups

Tertiary amine (-N(CH3)2), hydroxyl group (-OH)

Physical State

Clear liquid

Odor

Mild, amine-like

Common Uses

Synthetic intermediate in pharmaceutical production
Organic synthesis processes

Safety Measures

Requires strict handling and storage measures
Potential hazards if not managed properly

Upstream product

• 7221-41-2 N-benzyl-2-hydroxy-N,N-dimethylethanammonium bromide 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 89-92-9 2-methylbenzyl bromide 
• 67625-13-2 3-Methyl-2-o-tolyl-oxazolidine 
• 933-88-0 ortho-toluoyl chloride 
• 529-20-4 2-methylphenyl aldehyde 
• 100-39-0 benzyl bromide 

Downstream Products

• 96116-93-7 o-Xylyl-<2-hydroxy-aethyl>-dimethylammonium-iodid 
• 1206549-06-5 N-(2-hydroxyethyl)-N-(methoxycarbonylmethyl)-N-methyl-N-(2-methylbenzyl)ammonium bromide 

Relevant articles and documents

Resolution of nitrogen-centered chiral tetraalkylammonium salts: application to [1,2] Stevens rearrangements with N-to-C chirality transmission

The resolution of N-chiral, amino acid-derived quaternary ammonium salts is demonstrated by using chiral BINOL as a complexing agent. Determination of the enantiopurities and absolute configurations of the resolved N-chiral tetraalkylammonium salts are described. The [1,2] Stevens rearrangement of N-chiral ammonium salts is shown to proceed with N-to-C chirality transmission to afford optically active 3-substituted morpholin-2-one derivatives.

Synthesis of N-(dialkylaminoalkyl)alcohols by homogeneously catalyzed hydrogenolysis of cyclic N,O-acetals

The homogeneously catalyzed hydrogenation of 1,3-oxazolidines affording unsymmetrically substituted 2-N-(dialkylamino)ethanols is reported showing for the first time that Rh(I) catalysts based on chelating diphosphines can be advantageous for this reaction.