946593-11-9

Basic information

• Product Name: 1-N-BOC-4-(4-CHLOROPHENYL)PIPERIDINE
• Synonyms: 4-(4-Chloro-phenyl)-piperidine-1;1-N-BOC-4-(4-CHLOROPHENYL)PIPERIDINE;1-Boc-4-(4-Chlorophenyl)piperidine
• CAS NO: 946593-11-9
• Molecular Formula: C16H22ClNO2
• Molecular Weight: 295.808
• Mol File: 946593-11-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 384.8°C at 760 mmHg
• Flash Point: 186.5°C
• Appearance: /
• Density: 1.134g/cm³
• Vapor Pressure: 3.98E-06mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: 2-8°C
• PKA: -1.75±0.40(Predicted)
• CAS DataBase Reference: 1-N-BOC-4-(4-CHLOROPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-BOC-4-(4-CHLOROPHENYL)PIPERIDINE(946593-11-9)
• EPA Substance Registry System: 1-N-BOC-4-(4-CHLOROPHENYL)PIPERIDINE(946593-11-9)

Safety Data

• Hazardous Substances Data: 946593-11-9(Hazardous Substances Data)

Usage

General Description

1-N-BOC-4-(4-chlorophenyl)piperidine is a chemical compound that is often used in the synthesis of pharmaceuticals and other organic compounds. It is a piperidine derivative with a BOC (tert-butyloxycarbonyl) protecting group attached to the nitrogen atom. The compound has a 4-chlorophenyl group attached to the piperidine ring, providing it with unique chemical and biological properties. It is commonly used as an intermediate in the production of various drugs, including antipsychotic and analgesic medications. Additionally, it has been studied for its potential use in the treatment of neurological disorders and as a precursor for the development of new chemical compounds with therapeutic effects.

InChI:InChI=1/C16H22ClNO2/c1-16(2,3)20-15(19)18-10-8-13(9-11-18)12-4-6-14(17)7-5-12/h4-7,13H,8-11H2,1-3H3

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 235109-63-4 4-(4-chloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 637-87-6 1-Chloro-4-iodobenzene 
• 138647-50-4 4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1510865-53-8 tert-butyl 4-(2-((4-methoxyphenyl)sulfonyl)hydrazono)piperidine-1-carboxylate 
• 1679-18-1 4-Chlorophenylboronic acid 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1872262-73-1 1-(tert-butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate 
• 106-39-8 bromochlorobenzene 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 

Downstream Products

• 26905-02-2 4-(4-chlorophenyl)piperidine 

Relevant articles and documents

TRPML MODULATORS

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Design, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents

Epilepsy is a kind of disease with complicated pathogenesis. KCNQ (Kv7) is a voltage dependent potassium channel that is mostly associated with epilepsy and thus becomes an important target in the treatment of epilepsy. In this paper, a series of substituted piperidine derivatives targeting KCNQ were designed and synthesized by using scaffold hopping and active substructure hybridization. Compounds were evaluated by fluorescence-based thallium influx assay, Rb+ flow assay and electrophysiological patch-clamp assay. Results showed that some compounds possessed more potent potassium channel opening activity than Retigabine. More significantly, compound 11 was found to have good pharmacokinetic profiles in vivo.

Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids

A transformation analogous in simplicity and functional group tolerance to the venerable Suzuki cross-coupling between alkyl-carboxylic acids and boronic acids is described. This Ni-catalyzed reaction relies upon the activation of alkyl carboxylic acids as their redox-active ester derivatives, specifically N-hydroxy-tetrachlorophthalimide (TCNHPI), and proceeds in a practical and scalable fashion. The inexpensive nature of the reaction components (NiCl2?6 H2O—$9.5 mol?1, Et3N) coupled to the virtually unlimited commercial catalog of available starting materials bodes well for its rapid adoption.