94714-36-0

Basic information

• Product Name: 1H-Imidazole, 4-(2-phenylethyl)-
• CAS NO: 94714-36-0
• Molecular Formula: C11H12N2
• Molecular Weight: 172.23
• Mol File: 94714-36-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole, 4-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 4-(2-phenylethyl)-(94714-36-0)
• EPA Substance Registry System: 1H-Imidazole, 4-(2-phenylethyl)-(94714-36-0)

Safety Data

• Hazardous Substances Data: 94714-36-0(Hazardous Substances Data)

Upstream product

• 30718-17-3 trimethylsilylmethyl isocyanide 
• 645-59-0 dihydrocinnamonitrile 
• 104-53-0 3-phenyl-propionaldehyde 
• 3473-63-0 formamidine acetic acid 
• 153683-49-9 2-bromo 4-phenylbutyraldehyde 

Downstream Products

• 869967-19-1 4-(2-phenylethyl)-1-(triphenylmethyl)-1H-imidazole 
• 869967-24-8 2-[4-(2-phenylethyl)-1-(triphenylmethyl)-1H-imidazol-2-yl]-2-(triphenylmethoxy)ethanol 
• 869967-32-8 N-benzyl-N-{[4-(2-phenylethyl)-1-(triphenylmethyl)-1H-imidazol-2-yl]methyl}acetamide 
• 869967-30-6 2-[(benzylamino)methyl]-4-(2-phenylethyl)-1-(triphenylmethyl)-1H-imidazole 
• 869967-22-6 4-(2-phenylethyl)-1-(triphenylmethyl)-1H-imidazole-2-methanol 
• 869967-20-4 4-(2-phenylethyl)-1-(triphenylmethyl)-1H-imidazole-2-carbaldehyde 

Relevant articles and documents

Process for the synthesis of imidazoles

The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active compounds and/or intermediates for the preparation of pharmacologically-active compounds.

Novel farnesyl protein transferase inhibitors as antitumor agents

Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

A Two-Step Synthesis of Imidazoles from Aldehydes via 4-Tosyloxazolines

Imidazoles with substituents in the 4- and 4,5-positions were prepared by heating 4-tosyloxazolines in saturated methanolic ammonia.Similar treatment of these oxazolines with monoalkylamines regioselectively affords 1,4-disubstituted imidazoles.When oxazolines bearing an ethyl group at the 4-position were heated with alkylamines, however, a regioisomeric mixture of di- or trisubstituted imidazoles was produced.These reactions proceed via an intermolecular condensation of α-amino ketones and amidines or intramolecular cyclization of α-amidino ketone intermediates, respectively.