94796-13-1Relevant articles and documents
A method for synthesizing spore parent nucleus antibiotiki head
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, (2017/01/02)
The invention belongs to the technical field of synthesis of cephalosporin intermediates and in particular relates to a synthesis method of antibiotic cephalosporin mother nucleus. The synthesis method of the antibiotic cephalosporin mother nucleus comprises the following steps: (1) preparing a reaction liquid I; (2) preparing a reaction liquid II; (3) preparing a compound GVNA; and (4) preparing AVNA. The synthesis method of the antibiotic cephalosporin mother nucleus has the advantages that production cost is low, reaction time is short, recovery rate of the organic solvent is high, secondary utilization is facilitated, and product yield is high.
Reductive cross-coupling of 3-substituted Δ3-cephems with alkenyl halides in an Al/PbBr2/NiBr2(bpy) triplemetal redox system. Synthesis of 3-alkenyl-Δ3-cephems
Tanaka,Zhao,Kumase
, p. 570 - 577 (2007/10/03)
Synthesis of 3-alkenyl-Δ3-cephems was performed successfully by cross-coupling 3-(trifluoromethylsulfonyloxy or chloro)-Δ3-cephem with alkenyl halides, e.g., vihyl bromide, trans-1-bromo-1-propene, and trans-β-bromostyrene in an Al/cat·PbBr2/cat·NiBr2(bpy)/NMP (or DMF) system. Reduction of 3-(trifluoromethylsulfonyloxy)-Δ3-cephem into norcephalosporin was also achieved by a similar reaction in the presence of 5 molar equiv of water. Scope and a plausible mechanism of the Al/Pb/Ni triplemetal-redox promoted reactions are discussed.
A facile synthesis of cephem side chains by palladium catalyzed cross- coupling of 3-substituted-δ3-cephems with dialkylzinc or vinyltributyltin
Contento, Michele,Da Col, Marco,Galletti, Paola,Sandri, Sergio,Umani-Ronchi, Achille
, p. 8743 - 8746 (2007/10/03)
Synthesis of 3-vinyl- and 3-alkyl-Δ3-cephems was performed in a regioselective manner by palladium acetate catalyzed reaction of 3-sulfonato- or 3-bromo-Δ3-cephems with dialkylzinc or vinyltributyltin. A new access to 3-alkyl-Δ3-cephems is opened, starting from the allenyl compound 10.