948-54-9

Basic information

• Product Name: 1-(Bromophenylmethyl)-4-chlorobenzene
• Synonyms: 1-(Bromophenylmethyl)-4-chlorobenzene
• CAS NO: 948-54-9
• Molecular Formula: C₁₃H₁₀BrCl
• Molecular Weight: 281.5755
• Mol File: 948-54-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 334.4°Cat760mmHg
• Flash Point: 184.8°C
• Appearance: /
• Density: 1.446g/cm³
• Vapor Pressure: 0.000249mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 1-(Bromophenylmethyl)-4-chlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Bromophenylmethyl)-4-chlorobenzene(948-54-9)
• EPA Substance Registry System: 1-(Bromophenylmethyl)-4-chlorobenzene(948-54-9)

Safety Data

• Hazardous Substances Data: 948-54-9(Hazardous Substances Data)

Usage

General Description

1-(Bromophenylmethyl)-4-chlorobenzene is a chemical compound with the molecular formula C13H10BrCl. It is a colorless solid with a molecular weight of 261.57 g/mol. 1-(Bromophenylmethyl)-4-chlorobenzene is used in organic synthesis and research as a building block for the preparation of various pharmaceuticals, agrochemicals, and other specialty chemicals. It is also used as a reagent in chemical reactions and as a starting material for the synthesis of other organic compounds. The compound is toxic and can be harmful if ingested or inhaled, so proper handling and safety precautions should be taken when working with it.

InChI:InChI=1/C13H10BrCl/c14-13(10-4-2-1-3-5-10)11-6-8-12(15)9-7-11/h1-9,13H

Upstream product

• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 134-85-0 4-chlorobenzophenone 

Downstream Products

• 93454-47-8 4-chlorodiphenymethyl p-toluenethiosulfonate 
• 10203-73-3 4-Chlor-benzhydryl-thiocyanat 
• 76194-47-3 diethyl <(4-chlorophenyl) phenylmethyl> phosphonate 
• 16821-61-7 -aethyl-aether 
• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 831-81-2 4-chlorophenyl(phenyl)methane 
• 97027-07-1 4-Chlor-diphenyl-methyl-phosphonsaeure 
• 2484-99-3 4-chloro-thiobenzophenone 
• 153785-60-5 <(4-chlorophenyl)phenylmethylene>triphenylphosphorane 
• 21333-49-3 4-chlorobenzhydryl isothiocyanate 
• 21333-50-6 N-<4-Chlor-benzhydryl>-N'-phenyl-thioharnstoff 
• 820971-76-4 methyl {1-[(4-chlorophenyl)(phenyl)methyl]azetidin-3-ylidene}(3,5-difluorophenyl)acetate hydrochloride 
• 820971-79-7 methyl {1-[(4-chlorophenyl)(phenyl)methyl]azetidin-3-yl}(3,5-difluorophenyl)acetate 
• 66148-70-7 2-(p-Chlorobenzhydryl) octahydro-1H-pyrrolo[1,2-a][1,4]diazepine 

Relevant articles and documents

An efficient and selective method for the iodination and bromination of alcohols under mild conditions

A straightforward and effective procedure for the conversion of a variety of alcohols into the corresponding alkyl iodides and bromides is described using KX/P2O5 (X = I, Br). The reactions were easily carried out in acetonitrile under mild conditions. Using this method, the selective conversion of benzylic alcohols in the presence of aliphatic alcohols was achieved.

Kinetics of the solvolyses of benzhydryl derivatives: Basis for the construction of a comprehensive nucleofugality scale

A series of 21 benzhydrylium ions (diarylmethylium ions) are proposed as reference electrofuges for the development of a general nucleofugality scale, where nucleofugality refers to a combination of leaving group and solvent. A total of 167 solvolysis rate constants of benzhydrylium tosylates, bromides, chlorides, trifluoroacetates, 3,5-dinitrobenzoates, and 4-nitroben-zoates, two-thirds of which have been determined during this work, were subjected to a least-squares fit according to the correlation equation log k 25°C = Sf(Nf + Ef), where s f and Nf are nucleofuge-specific parameters and E f is an electrofuge-specific parameter. Although nucleofuges and electrofuges characterized in this way cover more than 12 orders of magnitude, a single set of the parameters, namely sf, Nf, and E f, is sufficient to calculate the solvolysis rate constants at 25°C with an accuracy of ± 16%. Because sf ≈ 1 for all nucleofuges, that is, leaving group/ solvent combinations, studied so far, qualitative discussions of nucleofugality can be based on Nf.

Benzylphosphonic acid inhibitors of human prostatic acid phosphatase

A series of α-substituted benzylphosphonic acids is described as inhibitors of human prostatic acid phosphatase, an enzyme has been used as a model to study aryl phosphatases. The most potent inhibitors in this series are 2-trifluoromethylbenzhydrylphosphonic acid (9 μM), and α-(2-phenylethyl)benzylphosphonic acid (14 μM). The structure-activity studies suggest that bulk tolerance beyond the phosphate binding area limits the steric or hydrophobic contribution to inhibitor potency achieved through α-carbon substitution.