949892-17-5

Basic information

• Product Name: 1-bromo-2-methoxy-4-(methoxymethoxy)benzene
• Synonyms: 1-bromo-2-methoxy-4-(methoxymethoxy)benzene
• CAS NO: 949892-17-5
• Molecular Weight: 247.089
• Mol File: 949892-17-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-bromo-2-methoxy-4-(methoxymethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-methoxy-4-(methoxymethoxy)benzene(949892-17-5)
• EPA Substance Registry System: 1-bromo-2-methoxy-4-(methoxymethoxy)benzene(949892-17-5)

Safety Data

• Hazardous Substances Data: 949892-17-5(Hazardous Substances Data)

Upstream product

• 102127-34-4 4-bromo-3-methoxyphenol 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 199858-19-0 2-methoxy-4-methoxymethoxyphenylboronic acid 
• 133740-28-0 (2,4-dihydroxyphenyl)((2S,3S,3aS,4S,9bR)-7-hydroxy-2,4-bis(4-hydroxyphenyl)-2,3,3a,9b-tetrahydro-4H-furo[3,2-c]chromen-3-yl)methanone 

Relevant articles and documents

Combined directed metalation-cross coupling strategies. Total synthesis of the aglycones of gilvocarcin V, M and E

Using the versatile Directed ortho and remote Metalation protocols linked with Suzuki-Miyaura cross coupling, efficient syntheses of defucogilvocarcin V, M, and E, 2-4 have been achieved.

A Novel Compound For Regulating Circadian Rhythm And A Use Thereof

The present invention relates to a novel compound which shows activities dependent on a crucial gene Rev-erbandalpha; constituting biological clock, and enables the production of pharmaceutical compositions for regulating biorhythms containing the novel c

Combined directed remote metalation-transition metal catalyzed cross coupling strategies: The total synthesis of the aglycones of the gilvocarcins V, M, and E and arnottin I

(Chemical Equation Presented) A key directed remote metalation (DreM)-carbamoyl migration strategy was applied in an efficient synthesis of the naturally occurring 6H-naphtho[1,2-b]benzopyran-6-one defucogilvocarcin V (1a, Scheme 11). The required biarylcarbamate 33d was best prepared by a high yielding Suzuki coupling reaction of 31a with the differentially protected trioxygenated naphthalene coupling partner 32d which was synthesized using a selective acylation of a juglone derivative. In the late stages of the synthesis, the triflate 39 served as the common intermediate to install the required C-8 vinyl group of 1a (Stille coupling) as well as the required substituents for the preparation of defucogilvocarcins M (1b) and E (1c). A variety of protecting group strategies were investigated and provided insight into which groups are preferred for the DreM-carbamoyl migration process. The strategic lessons learned from this total synthesis were applied in the successful total synthesis of the structurally similar natural product arnottin I (2).