95018-22-7

Basic information

• Product Name: Pyridine, 1-[[(1,1-dimethylethyl)imino]methyl]-1,2,3,4-tetrahydro-6-(phenylmethyl)-
• CAS NO: 95018-22-7
• Molecular Formula: C17H24N2
• Molecular Weight: 256.391
• Mol File: 95018-22-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyridine, 1-[[(1,1-dimethylethyl)imino]methyl]-1,2,3,4-tetrahydro-6-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 1-[[(1,1-dimethylethyl)imino]methyl]-1,2,3,4-tetrahydro-6-(phenylmethyl)-(95018-22-7)
• EPA Substance Registry System: Pyridine, 1-[[(1,1-dimethylethyl)imino]methyl]-1,2,3,4-tetrahydro-6-(phenylmethyl)-(95018-22-7)

Safety Data

• Hazardous Substances Data: 95018-22-7(Hazardous Substances Data)

Upstream product

• 95018-15-8 tert-Butyl-[1-(2-phenylselanyl-piperidin-1-yl)-meth-(E)-ylidene]-amine 
• 85152-52-9 N-(N'-tert-butylformimidoyl)piperidine 
• 89656-61-1 tert-Butyl-[1-(3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine 
• 40400-13-3 2-Iodobenzyl bromide 
• 100-39-0 benzyl bromide 

Downstream Products

• 32838-55-4 2-benzylpiperidine 
• 95018-41-0 2-benzyl-3,4,5,6-tetrahydropyridine 

Relevant articles and documents

Aryl Radical Endo Cyclization of Enamidines. Selective Preparation of Trans and Cis Fused Octahydrobenzo[f]quinolines

Aryl radicals from N-protected 6-[2-(2-halophenyl)ethyl]-1,2,3,4-tetrahydropyridines and 6-[3-(2-halophenyl)propyl]-1,2,3,4-tetrahydropyridines undergo intramolecular cyclization onto the enamide/ enamidine double bond by 6-endo and 7-endo closure, respectively. In the 6-endo cyclization the trans/cis ratio of the formed N-protected octahydrobenzo[f]quinoline can be controlled, and selective synthesis of either the trans or the cis isomer can be achieved with triphenyltin hydride and tris(trimethylsilyl)silicon hydride, respectively. In the 7-endo cyclization to N-protected octahydro-1H-benzo[3,4]cyclohepta[1,2-b]pyridine, the trans fused isomer predominates, although the selectivity is low. The oxidized cyclization products, with a restored enamide/enamidine double bond, are formed at low concentrations of tris(trimethylsilyl)silicon hydride.