95290-23-6

Basic information

• Product Name: N-[2-(4-benzyloxy-3-methoxyphenyl)ethyl]-3-methylbutyramide
• CAS NO: 95290-23-6
• Molecular Weight: 341.45
• Mol File: 95290-23-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[2-(4-benzyloxy-3-methoxyphenyl)ethyl]-3-methylbutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(4-benzyloxy-3-methoxyphenyl)ethyl]-3-methylbutyramide(95290-23-6)
• EPA Substance Registry System: N-[2-(4-benzyloxy-3-methoxyphenyl)ethyl]-3-methylbutyramide(95290-23-6)

Safety Data

• Hazardous Substances Data: 95290-23-6(Hazardous Substances Data)

Upstream product

• 63909-38-6 3-methoxy-4-benzyloxy-ω-nitrostyrolene 
• 22231-61-4 2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine 
• 108-12-3 isopentanoyl chloride 

Downstream Products

• 122765-87-1 7-benzyloxy-1-isobutyl-6-methoxy-2-methyl-3,4-dihydro-isoquinolinium; iodide 
• 95160-06-8 7-benzyloxy-1-isobutyl-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline 
• 19485-63-3 Lophocerin 
• 97254-91-6 7-benzyloxy-1-isobutyl-6-methoxy-3,4-dihydro-isoquinoline 

Relevant articles and documents

-

-

1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES

Provided are 7-hydroxy-6-methoxy-l,2,3,4-tetrahydroisoquinoline derivatives and synthesis methods thereof. The compounds significantly inhibit the production of nitrogen monoxide (NO) and superoxide in an activated microglial cell and expressions of TNF-α, IL- lβ inducive NO synthase and cyclooxygenase-2 genes. They also prevent NF-kB shift to a nucleus, decrease reactive oxygen species (ROS), inhibit expression of GTP cyclohydrolase I gene and over-production of tetrahydrobiopterin (BH 4 ), and protect dopaminergic neurons from injury due to activated microglial cells. Consequently, the compounds are effective in treating inflammatory and neurodegenerative diseases.