95388-01-5

Basic information

• Product Name: DL-GLUTAMIC-5-13C ACID
• Synonyms: DL-GLUTAMIC-5-13C ACID, 99 ATOM % 13C;DL-Glutamic acid-5-13C;DL-GLUTAMIC-5-13C ACID
• CAS NO: 95388-01-5
• Molecular Formula: C5H9NO4
• Molecular Weight: 148.14
• Product Categories: Alphabetical Listings;G-H;Stable Isotopes
• Mol File: 95388-01-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 185 °C (dec.)(lit.)
• Appearance: /
• Density: 1.409 g/cm³
• Refractive Index: 1.522
• CAS DataBase Reference: DL-GLUTAMIC-5-13C ACID(CAS DataBase Reference)
• NIST Chemistry Reference: DL-GLUTAMIC-5-13C ACID(95388-01-5)
• EPA Substance Registry System: DL-GLUTAMIC-5-13C ACID(95388-01-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 95388-01-5(Hazardous Substances Data)

Usage

General Description

DL-GLUTAMIC-5-13C ACID is a chemical compound that is derived from glutamic acid, an important amino acid. The "DL" prefix indicates that the compound is a racemic mixture, meaning it contains both the D and L forms of the molecule. The "5-13C" notation indicates that the compound contains carbon-13 isotope at the 5th position on the carbon chain. This isotopic labeling is commonly used in research and biochemical studies to track the metabolic pathways and biochemical reactions involving glutamic acid. DL-GLUTAMIC-5-13C ACID is often used as a tracer in metabolic studies, allowing researchers to analyze the uptake, utilization, and conversion of glutamic acid in various biological processes.

InChI:InChI=1/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/i4+1

Upstream product

• 108395-16-0 C₄⁽¹³⁾CH₆O₅ 
• 135053-02-0 C₈⁽¹³⁾CH₁₄O₅ 
• 135052-98-1 C₈⁽¹³⁾CH₁₅NO₆ 
• 25909-68-6 [¹³C]-potassium cyanide 
• 33667-01-5 <13-C>cyanide 
• 13602-48-7 3-benzoylamino-dihydro-furan-2-one 
• 59681-32-2 ¹³C₅-¹⁵N₂-L-glutamine 
• 1259016-65-3 (2S)-[2,3,4,5,6-⁽¹³⁾C₅;1-⁽¹⁵⁾N]N-tert-butoxycarbonyl-5-(tert-butyldimethylsilyloxymethyl)-1H-pyrrol-2(5H)-one 
• 554428-67-0 (2S,3S,4R)-[3,4-⁽²⁾H₂;2,3,4,5,6-⁽¹³⁾C₅;1-⁽¹⁵⁾N]N-tert-butoxycarbonyl-5-(tert-butyldimethylsilyloxymethyl)pyrrolidin-2-one 
• 1259016-71-1 C₅⁽¹³⁾C₅H₁₃⁽²⁾H₂⁽¹⁵⁾NO₅ 

Downstream Products

• 159680-32-7 (5-13C)-L-Glutamine 
• 554428-63-6 (2S,3S,4R)-[1,2,3,4,5-13C5;2,5-13N2;3,4-2H2]glutamine 
• 554429-02-6 SAIL proline 
• 1220967-81-6 C₇⁽¹³⁾C₅H₁₄N₂O₅ 
• 1220967-83-8 C₉⁽¹³⁾C₅H₁₆N₂O₆ 

Relevant articles and documents

The Biosynthesis of Showdomycin: Studies with Stable Isotopes and the Determination of Principal Precursors

Studies with stable isotopes show that D-ribose and L-glutamic acid are direct biosynthetic precursors of showdomycin (1), with carbons 2-5 and the nitrogen of L-glutamate giving rise to the maleimide ring: L-pyroglutamate may be an intermediate.

Specific detection of cellular glutamine hydrolysis in live cells using HNCO triple resonance NMR

Glutamine plays key roles as a biosynthetic precursor or an energy source in cancers, and interest in its metabolism is rapidly growing. However, the proper evaluation of glutamine hydrolysis, the very first reaction in the entire glutaminolysis, has been difficult. Here, we report a triple resonance NMR-based assay for specific detection of glutaminase activity carrying out this reaction using stable-isotope labeled glutamine. Compared to conventional methods involving coupled enzyme assays, the proposed approach is direct because it detects the presence of the H-N-CO amide spin system. In addition, the method is unique in enabling the measurement of glutamine hydrolysis reaction in real-time in live cells. The approach was applied to investigating the effects of a glutaminase inhibitor and the inhibitory effects of glucose on glutamine metabolism in live cells. It can be easily applied to studying other signals that affect cellular glutamine metabolism.

Carbapenem biosynthesis: Confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-Proline

(5R)-Carbapen-2-em-3-carboxylic acid is the simplest structurally among the naturally occurring carbapenem β-lactam antibiotics. It co-occurs with two saturated (3S,5S)- and (3S,5R)-carbapenam carboxylic acids. Confusion persists in the literature about t