956001-37-9

Basic information

• Product Name: (S)-tert-butyl (cyano(4-fluorophenyl)methyl)carbamate
• Synonyms: (S)-tert-butyl (cyano(4-fluorophenyl)methyl)carbamate
• CAS NO: 956001-37-9
• Molecular Weight: 250.273
• Mol File: 956001-37-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl (cyano(4-fluorophenyl)methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl (cyano(4-fluorophenyl)methyl)carbamate(956001-37-9)
• EPA Substance Registry System: (S)-tert-butyl (cyano(4-fluorophenyl)methyl)carbamate(956001-37-9)

Safety Data

• Hazardous Substances Data: 956001-37-9(Hazardous Substances Data)

Upstream product

• 956000-05-8 (S)-N-(tert-butoxycarbonyl)-(4-fluorophenyl)glycinamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 19883-57-9 (S)-2-amino-2-(4-fluorophenyl)acetic acid 
• 142186-36-5 (S)-2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid 

Relevant articles and documents

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure

Structure-activity relationships (SAR) of 1 against HCV NS5B polymerase were described. SAR explorations and further structure-based design led to the identifications of 2 and 3 as novel HCV NS5B inhibitors. X-ray structure of 3 in complex with NS5B polymerase was obtained at a resolution of 2.2 A, and confirmed the design.