956010-87-0

Basic information

• Product Name: 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
• Synonyms: 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridine, 3-(trifluoroMethyl)-;3-Trifluomethyl-7-aza-1H-indazloe;3-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridine
• CAS NO: 956010-87-0
• Molecular Formula: C₇H₄F₃N₃
• Molecular Weight: 187.124
• Mol File: 956010-87-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 284.586 °C at 760 mmHg
• Flash Point: 125.914 °C
• Appearance: /
• Density: 1.536 g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine(956010-87-0)
• EPA Substance Registry System: 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine(956010-87-0)

Safety Data

• Hazardous Substances Data: 956010-87-0(Hazardous Substances Data)

Usage

General Description

3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine is a chemical compound with the molecular formula C7H4F3N3. It belongs to the class of pyrazolopyridine compounds and contains a trifluoromethyl substituent. 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine has potential applications in pharmaceutical and agrochemical industries due to its unique chemical structure and properties. It may be used as a building block for the synthesis of novel drugs, or as an active ingredient in pesticides. Its specific uses and potential effects on human health and the environment would need to be carefully evaluated before any practical applications.

InChI:InChI=1/C7H4F3N3/c8-7(9,10)5-4-2-1-3-11-6(4)13-12-5/h1-3H,(H,11,12,13)

Upstream product

• 886371-13-7 C₇H₃BrF₃NO 
• 1186608-79-6 2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethanone 
• 372-48-5 2-fluoropyridine 
• 383-63-1 ethyl trifluoroacetate, 
• 1092459-51-2 1-(2-bromo-3-pyridinyl)-2,2,2-trifluoroethanol 
• 128071-75-0 2-bromopyridine-3-carboxaldehyde 

Downstream Products

• 1186608-80-9 5-nitro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine 
• 956010-88-1 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 1186608-81-0 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine-5-amine 
• 1260535-32-7 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine 7-oxide 
• 1256802-09-1 4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine 
• 1260535-36-1 3-{3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl}quinoline 
• 1260535-39-4 2-Bromo-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile 
• 1260535-41-8 2-(trans-4-hydroxycyclohexylamino)-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile 
• 1260531-31-4 2-(trans-4-hydroxycyclohexylamino)-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide 
• 1260538-70-2 3-methyl-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile 
• 256376-65-5 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 956010-86-9 1-(2-fluorobenzyl)-N'-hydroxy-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide 
• 956011-33-9 3-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-oxadiazole-5(4H)-thione 
• 956011-28-2 3-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-thiadiazol-5(4H)-one 

Relevant articles and documents

Use of 3-(trifluoromethyl)-1H-pyrazolo-[3,4-b]pyridine as a versatile building block

A one-pot multigram synthesis of 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine starting from 2-fluoropyridine using directed ortho metallation (DoM) technique is described. The compound contains an anionically activatable trifluoromethyl group and is a versatile building block for the microwave assisted synthesis of 3-substituted 1H-pyrazolo[3,4-b]pyridines.

AZABICYCLO COMPOUND AND SALT THEREOF

It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein X1 represents CH or N; any one of X2, X3 and X4 represents N, and the others represent CH; any one or two of Y1, Y2, Y3 and Y4 represent C—R4, and the others are the same or different and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R3 and R4 represent —CO—R5 or the like.

Heterocyclic Substituted, Anellated Pyrazole Derivative and its uses

The present application relates to novel heterocyclyl-substituted fused pyrazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.