956010-88-1

Basic information

• Product Name: 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
• Synonyms: 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile;1H-pyrazolo[3;4-b]pyridine-3-carbonitrile;2H-pyrazolo[3,4-b]pyridine-3-carbonitrile
• CAS NO: 956010-88-1
• Molecular Formula: C₇H₄N₄
• Molecular Weight: 144.13346
• EINECS: -0
• Mol File: 956010-88-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 397.1±22.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.78±0.40(Predicted)
• CAS DataBase Reference: 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile(956010-88-1)
• EPA Substance Registry System: 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile(956010-88-1)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 956010-88-1(Hazardous Substances Data)

Usage

General Description

1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile is a chemical compound with the molecular formula C8H5N5. It is a heterocyclic compound that contains a pyrazole and pyridine ring fused together, and a nitrile group attached to the third position of the pyrazole ring. 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile has potential pharmaceutical applications and has been studied for its anticancer and anti-inflammatory properties. It is also used as a building block in the synthesis of various bioactive compounds. 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile is of interest to researchers and the pharmaceutical industry for its potential therapeutic benefits.

Upstream product

• 956010-87-0 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine 
• 557-21-1 zinc(II) cyanide 
• 117007-52-0 3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 36404-88-3 2-chloro-3-carbaldehydepyridine 
• 271-73-8 1H-Pyrazolo[3,4-b]pyridine 
• 372-48-5 2-fluoropyridine 
• 1186608-79-6 2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethanone 
• 68618-36-0 3-Bromo-1H-pyrazolo<3,4-b>pyridine 
• 6752-16-5 1H-pyrazolo[3,4-b]pyridin-3-amine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Downstream Products

• 256376-65-5 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 627076-46-4 1-(2,3-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 956291-23-9 1-(Cyclohexylmethyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 956010-86-9 1-(2-fluorobenzyl)-N'-hydroxy-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide 
• 956011-33-9 3-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-oxadiazole-5(4H)-thione 
• 956011-28-2 3-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-thiadiazol-5(4H)-one 
• 956011-27-1 3-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-oxadiazol-5(4H)-one 
• 956291-13-7 1-(Cyclohexylmethyl)-3-(1H-tetrazol-5-yl)-1H-pyrazolo[3,4-b]pyridine 
• 956291-15-9 1-(2,3-Difluorobenzyl)-3-(1H-tetrazol-5-yl)-1H-pyrazolo[3,4-b]pyridine 

Relevant articles and documents

SGC STIMULATORS

The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an inc

Use of 3-(trifluoromethyl)-1H-pyrazolo-[3,4-b]pyridine as a versatile building block

A one-pot multigram synthesis of 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine starting from 2-fluoropyridine using directed ortho metallation (DoM) technique is described. The compound contains an anionically activatable trifluoromethyl group and is a versatile building block for the microwave assisted synthesis of 3-substituted 1H-pyrazolo[3,4-b]pyridines.

Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b] pyridines as soluble guanylate cyclase stimulators

Novel guanylate cyclase stimulators are disclosed. Design, synthesis, SAR, and pharmacological profile of the compounds are discussed.