958867-87-3Relevant articles and documents
A novel strategy to assemble the β-diketo acid pharmacophore of HIV integrase inhibitors on purine nucleobase scaffolds
Uchil, Vinod,Seo, Byung,Nair, Vasu
, p. 8577 - 8579 (2008/02/13)
(Chemical Equation Presented) Claisen condensation, the key step in constructing the pharmacophore of aryl β-diketo acids (DKA) as integrase inhibitors, fails in certain cases of highly electron-deficient heterocycles such as purines. A general synthetic