96550-91-3

Basic information

• Product Name: 1-Propanone, 3-(1-naphthalenyl)-1-phenyl-
• CAS NO: 96550-91-3
• Molecular Formula: C19H16O
• Molecular Weight: 260.335
• Mol File: 96550-91-3.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 3-(1-naphthalenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-(1-naphthalenyl)-1-phenyl-(96550-91-3)
• EPA Substance Registry System: 1-Propanone, 3-(1-naphthalenyl)-1-phenyl-(96550-91-3)

Safety Data

• Hazardous Substances Data: 96550-91-3(Hazardous Substances Data)

Upstream product

• 96-09-3 styrene oxide 
• 4780-79-4 1-naphthalene methanol 
• 98-85-1 1-Phenylethanol 
• 35330-76-8 2-methanesulfinylnaphthalene 
• 90-15-3 α-naphthol 
• 99124-56-8 3-(1-naphthalenyl)propionyl chloride 
• 71-43-2 benzene 
• 98-86-2 acetophenone 
• 936-59-4 3-chloropropiophenone 
• 13922-41-3 1-Naphthylboronic acid 
• 90-11-9 1-Bromonaphthalene 
• 18020-59-2 methyl 3-hydroxy-2-methylidene-3-phenylpropionate 
• 80674-36-8 3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one 
• 42299-49-0 (E)-3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one 

Downstream Products

• 93-89-0 benzoic acid ethyl ester 
• 1423016-20-9 1,1,1-trifluoro-4-(naphthalen-1-yl)butan-2-one 
• 80674-36-8 3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one 
• 73981-95-0 1-(naphthalene-1-yl)-3-phenyl-1,3-propanedione 
• 29908-29-0 1-(α-naphthyl)-3-phenylpropane 

Relevant articles and documents

Nickel-Catalyzed Selective Synthesis of α-Alkylated Ketones via Dehydrogenative Cross-Coupling of Primary and Secondary Alcohols

Herein, we describe an isolable, air-stable, homogeneous, nickel catalyst that performs dehydrogenative cross-coupling reaction between secondary and primary alcohols to result α-alkylated ketone products selectively. The sequence of steps involve in this one-pot reaction is dehydrogenation of both alcohols, condensation between the ketone and the aldehyde, and hydrogenation of the in situ-generated α,β-unsaturated ketone. Preliminary mechanistic investigation hints a radical mechanism following borrowing hydrogen reaction. (Figure presented.).

Iridium Complexes as Efficient Catalysts for Construction of α-Substituted Ketones via Hydrogen Borrowing of Alcohols in Water

Ketones are of great importance in synthesis, biology, and pharmaceuticals. This paper reports an iridium complexes-catalyzed cross-coupling of alcohols via hydrogen borrowing, affording a series of α-alkylated ketones in high yield (86 %–95 %) and chemoselectivities (>99 : 1). This methodology has the advantages of low catalyst loading (0.1 mol%) and environmentally benign water as the solvent. Studies have shown the amount of base has a great impact on chemoselectivities. Meanwhile, deuteration experiments show water plays an important role in accelerating the reduction of the unsaturated ketones intermediates. Remarkably, a gram-scale experiment demonstrates this methodology of iridium-catalyzed cross-coupling of alcohols has potential application in the practical synthesis of α-alkylated ketones.

Method for preparing alpha-alkyl substituted ketone compound

The invention relates to a method for preparing an alpha-alkyl substituted ketone compound, which comprises the following steps: preparing a primary alcohol compound and a secondary alcohol compound as raw materials, adding alkali; with a cyclic iridium complex as a catalyst and water as a reaction medium, heating and stirring the mixture and reacting for 10 to 24 hours under the protection of inert gas, and cooling a reaction product to room temperature after the reaction is finished; carrying out reduced pressure distillation and concentration to obtain a crude product, and carrying out column chromatography purification to obtain a series of alpha alkyl substituted ketone compounds. The method is simple to operate, available in raw materials, low in price, high in reaction efficiency and selectivity, good in adaptability to various functional groups and wide in substrate universality; since water is used as a reaction medium to meet the green and environment-friendly requirements, the method is environmentally friendly and is carried out at gram level, so that the potential of industrially synthesizing the alpha alkyl substituted ketone compound is achieved; therefore, The method has expanded application in the fields of medicines, organic synthesis and the like.