96803-85-9

Basic information

• Product Name: Benzene, 1-[(2,2-diethoxyethyl)thio]-3-Methoxy-
• Synonyms: Benzene, 1-[(2,2-diethoxyethyl)thio]-3-Methoxy-;1-(2,2-diethoxyethylsulfanyl)-3-methoxybenzene
• CAS NO: 96803-85-9
• Molecular Formula: C₁₃H₂₀O₃S
• Molecular Weight: 256.3611
• Mol File: 96803-85-9.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 336.964°C at 760 mmHg
• Flash Point: 157.591°C
• Appearance: /
• Density: 1.077g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: Benzene, 1-[(2,2-diethoxyethyl)thio]-3-Methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(2,2-diethoxyethyl)thio]-3-Methoxy-(96803-85-9)
• EPA Substance Registry System: Benzene, 1-[(2,2-diethoxyethyl)thio]-3-Methoxy-(96803-85-9)

Safety Data

• Hazardous Substances Data: 96803-85-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H20O3S/c1-4-15-13(16-5-2)10-17-12-8-6-7-11(9-12)14-3/h6-9,13H,4-5,10H2,1-3H3

Upstream product

• 15570-12-4 3-methoxybenzenethiol 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 584-08-7 potassium carbonate 
• 7217-59-6 2-Methoxybenzenethiol 

Downstream Products

• 90560-10-4 6-methoxy-benzo[b]thiophene 
• 3781-90-6 4-methoxybenzo[b]thiophene 
• 105126-91-8 (3-methoxyphenylsulphanyl)acetaldehyde 
• 193965-80-9 4-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene 
• 193964-15-7 6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene 
• 193965-81-0 4-Hydroxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene 
• 193965-13-8 6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-Fluorophenyl Ketone 
• 96803-89-3 6-hydroxybenzothiophene-2-sulfonamide 
• 96803-92-8 6-acetoxybenzothiophene-2-sulfonamide 
• 43121-88-6 6-methoxy-benzo[b]thiophene-3-carboxylic acid 
• 1093631-86-7 methyl 6-(4-hydroxyphenyl)-1-benzothiophene-3-carboxylate 
• 1093631-87-8 methyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-3-carboxylate 
• 1093631-52-7 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-3-carboxylic acid 
• 183133-90-6 2-bromo-6-methoxybenzo[b]thiophene 

Relevant articles and documents

Concise synthesis and biological evaluation of 2-Aryl-3-Anilinobenzo[b]thiophene derivatives as potent apoptosis-inducing agents

Many clinically used agents active in cancer chemotherapy exert their activity through the induction of cell death (apoptosis) by targeting microtubules, altering protein function or inhibiting DNA synthesis. The benzo[b]thiophene scaffold holds a pivotal place as a pharmacophore for the development of anticancer agents, and, in addition, this scaffold has many pharmacological activities. We have developed a flexible method for the construction of a new series of 2-aryl-3-(3,4,5-trimethoxyanilino)-6-methoxybenzo[b]thiophenes as potent antiproliferative agents, giving access to a wide range of substitution patterns at the 2-position of the 6-methoxybenzo[b]thiophene common intermediate. In the present study, all the synthesized compounds retained the 3-(3,4,5-trimethoxyanilino)-6-methoxybenzo[b]thiophene moiety, and the structure–activity relationship was examined by modification of the aryl group at its 2-position with electron-withdrawing (F) or electron-releasing (alkyl and alkoxy) groups. We found that small substituents, such as fluorine or methyl, could be placed in the para-position of the 2-phenyl ring, and these modifications only slightly reduced antiproliferative activity relative to the unsubstituted 2-phenyl analogue. Compounds 3a and 3b, bearing the phenyl and para-fluorophenyl at the 2-position of the 6-methoxybenzo[b]thiophene nucleus, respectively, exhibited the greatest antiproliferative activity among the tested compounds. The treatment of both Caco2 (not metastatic) and HCT-116 (metastatic) colon carcinoma cells with 3a or 3b triggered a significant induction of apoptosis as demonstrated by the increased expression of cleaved-poly(ADP-ribose) polymerase (PARP), receptor-interacting protein (RIP) and caspase-3 proteins. The same effect was not observed with non-transformed colon 841 CoN cells. A potential additional effect during mitosis for 3a in metastatic cells and for 3b in non-metastatic cells was also observed.

NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF

The present invention relates to a new compound having an FGFR inhibitory activity and preparation and application thereof. In particular, the compound according to the present invention has a structure as shown in formula I, wherein each group and substituent are as defined in the description. Also disclosed in the present invention are a preparation method for the compound and a use thereof in preparation of a drug for treating and/or preventing a tumor-related disease and/or an FGFR-related disease.

ESTROGEN RECEPTOR-MODULATING COMPOUNDS

Described herein are compounds that are estrogen receptor modulators of formula I' Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.