96803-89-3Relevant articles and documents
Topically Active Carbonic Anhydrase Inhibitors. 2. Benzothiophenesulfonamide Derivatives with Ocular Hypotensive Activity
Graham, Samuel L.,Shepard, Kenneth L.,Anderson, Paul S.,Baldwin, John J.,Best, Darryl B.,et al.
, p. 2548 - 2554 (2007/10/02)
Derivatives of benzothiophene-2-sulfonamide were prepared to investigate their potential utility as topically active inhibitors of ocular carbonic anhydrase.Such an agent would be useful in the treatment of glaucoma.Among the compounds described are 6-hydroxybenzothiophene-2-sulfonamide (16) and its acetate ester (23), which are among the most potent ocular hypotensive agents in this class, as assessed in the α-chymotrypsinized rabbit.These compounds were selected for clinical evaluation.