96919-49-2

Basic information

• Product Name: 2-THIOPHEN-3-YL-PHENYLAMINE
• Synonyms: 2-THIOPHEN-3-YL-PHENYLAMINE;2-(3-THIENYL)ANILINE;AKOS BAR-0368;2-Thiophen-3-yl-phenylamine hydrochloride;[2-(3-thienyl)phenyl]amine;2-(thiophen-3-yl)aniline;BenzenaMine, 2-(3-thienyl)-;[2-(3-thienyl)phenyl]amine hydrochloride
• CAS NO: 96919-49-2
• Molecular Formula: C₁₀H₉NS
• Molecular Weight: 175.25
• Mol File: 96919-49-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 39-40 °C(Solv: hexane (110-54-3))
• Boiling Point: 277 °C at 760 mmHg
• Flash Point: 121.3 °C
• Appearance: /
• Density: 1.196
• Storage Temp.: 2-8°C
• PKA: 3.27±0.10(Predicted)
• CAS DataBase Reference: 2-THIOPHEN-3-YL-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-THIOPHEN-3-YL-PHENYLAMINE(96919-49-2)
• EPA Substance Registry System: 2-THIOPHEN-3-YL-PHENYLAMINE(96919-49-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 96919-49-2(Hazardous Substances Data)

Usage

General Description

2-Thiophen-3-yl-phenylamine is a chemical compound with the molecular formula C12H11NS. It is a derivative of phenylamine, in which a thiophene ring is attached to the 3-position of the phenyl ring. 2-THIOPHEN-3-YL-PHENYLAMINE is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It has been studied for its potential applications in medicinal chemistry, particularly in the development of new drugs for the treatment of various diseases. The compound possesses interesting chemical and pharmacological properties, making it a valuable building block in organic synthesis. Additionally, it may have potential applications in the fields of materials science and agrochemicals.

Upstream product

• 96919-48-1 3-(o-nitrophenyl)thiophene 
• 577-19-5 2-nitrophenyl bromide 
• 6165-69-1 Thien-3-ylboronic acid 
• 615-36-1 2-bromoaniline 

Downstream Products

• 2404-87-7 3-phenylthiophene 
• 1341197-63-4 4-(4-methoxy-phenyl)thieno-[2,3-c]quinoline 
• 233-04-5 thieno[2,3-c]quinoline 
• 1254221-31-2 trimethyl((2-(thiophen-3-yl)phenyl)ethynyl)silane 

Relevant articles and documents

Metal- and additive-free cascade trifluoroethylation/cyclization of organic isoselenocyanates by phenyl(2,2,2-trifluoroethyl)iodonium triflate

A novel and convenient cascade trifluoroethylation/cyclization of organic isoselenocyanates by phenyl(2,2,2-trifluoroethyl)iodonium triflate is reported. A series of 2-isoselenocyanobiaryls and aryl alkyl isoselenocyanates reacted with phenyl(2,2,2-trifluoroethyl)iodonium triflate in CH2Cl2 at 40 °C under metal- and additive-free conditions for 3 h to provide the corresponding trifluoroethylselenolated phenanthridines and 3,4-dihydroisoquinoline derivatives in good to excellent yields. The reaction represents the first general approach to access trifluoroethylselenolated phenanthridines and 3,4-dihydroisoquinolines from organic isoselenocyanates.

TfOH-Promoted Transition-Metal-Free Cascade Trifluoroethylation/Cyclization of Organic Isothiocyanates by Phenyl(2,2,2-trifluoroethyl)iodonium Triflate

An efficient and transition-metal-free method for the synthesis of the structurally diversified trifluoroethylthiol phenanthridines and 3,4-dihydroisoquinolines is described. Various 2-isothiocyanobiaryls and aryl alkyl isothiocyanates reacted with phenyl(2,2,2-trifluoroethyl)iodonium triflate in CH2Cl2 in the presence of trifluoromethanesulfonic acid at 40 °C to form the corresponding trifluoroethylation/cyclization products in good to quantitative yields. This work represents the first construction of trifluoroethylthiol phenanthridine and isoquinoline derivatives from isothiocyanates in the absence of transition-metal catalysts by a one-pot procedure.

Palladium-Catalyzed Synthesis of Tetrasubstituted Olefins by Triple Domino Process

An efficient, highly regio- and stereoselective protocol for the synthesis of tetrasubstituted olefins was developed to take place by a palladium(0)-catalyzed triple domino process. It involves the formation of three new C?C bonds through double carbopalladation and C?H activation across 2-bromoaryl alkynyl biaryls/heteroaryls with norbornene. This method is practically simple with broad substrate scope and tolerates a wide range of substituents. The products bearing 9H-pyrrolo[1,2-a]indole motifs reveal intriguing solid state fluorescence properties and thus form a new class of aggregation induced emission (AIE) fluorophores. (Figure presented.).