97302-05-1Relevant articles and documents
Direct C-C bond construction from arylzinc reagents and aryl halides without external catalysts
Minami, Hiroki,Wang, Xuan,Wang, Chao,Uchiyama, Masanobu
, p. 7891 - 7894 (2013)
Direct cross-coupling between an arylzinc reagent and an aryl halide was accomplished without any external catalyst, enabling efficient and selective formation of the corresponding biaryl compound with broad functional group compatibility. Direct cross-coupling between a diarylzinc compound and an aryl iodide was accomplished without using any external catalyst. The reaction is efficient and selective, enabling formation of the corresponding biaryl compounds with broad functional group compatibility. The reaction is proposed to proceed by a thermally initiated single electron transfer (SET) route. Copyright
FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
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Paragraph 00439-00440; 00487-00488, (2020/04/25)
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
One-pot Negishi cross-coupling reaction of aryldiazonium salts via Ni catalysis induced by visible-light
Wang, Lianjun,Liu, Gao
, (2019/08/29)
Visible-light induced catalysis is of high interest for its mild and environmentally benign properties. Herein, a general Ni catalysis accelerated by visible-light was successfully developed for one-pot Negishi coupling reactions at room temperature in a short reaction time (2Zn generated in situ from Grignard reagents and ZnBr2. This protocol provides a convenient access to C–C bond formation for important biaryl components. It tolerates various functional groups, and Hammett study illuminates the possiblility of Ni(III)/Ni(I) redox catalytic cycle.
