97546-25-3Relevant articles and documents
Efficient synthesis of 19-31 membered macrocyclic tetralactones via ring closing metathesis in ionic liquids
Muthusamy, Sengodagounder,Azhagan, Datschnamoorthy
scheme or table, p. 8196 - 8202 (2010/11/02)
The ring closing metathesis reaction in the presence of Grubbs catalyst was demonstrated using several ionic liquids to synthesize a range of macrocyclic tetralactones having ring size of 19 to 31 membered with different spacers. The ionic liquid [mmim][PF6] was found to be an excellent solvent and the recovery of the catalyst was demonstrated. X-ray analysis of a representative macrocyclic tetralactone was also reported.
Desymmetrization of cyclic anhydrides using dihydroxy compounds: Selective synthesis of macrocyclic tetralactones
Muthusamy, Sengodagounder,Gnanaprakasam, Boopathy,Suresh, Eringathodi
, p. 1913 - 1916 (2007/10/03)
The desymmetrization of cyclic anhydrides is carried out using dihydroxy compounds. A mild route to synthesize fused saturated/unsaturated macrocyclic tetralactones with different ring sizes (20-34) having a wide variety of spacers is described. The structure is confirmed by the representative single-crystal X-ray analysis. The multiple reduction of unsaturated macrocyclic tetralactones is also illustrated. This method is mild, selective, and efficient and achieves high yield.