37860-51-8

Basic information

• Product Name: TETRAETHYLENE GLYCOL DI-P-TOSYLATE
• Synonyms: BIS[2-(2-TOSYLOXYETHOXY)ETHYL] ETHER;BIS[2-[2-(P-TOLUENESULFONYLOXY)ETHOXY]ETHYL] ETHER;2,2'-(Ethylenedioxy)triethyl ditosylate;TETRAETHYLENE GLYCOL BIS(P-TOLUENESULFONATE);TETRAETHYLENE GLYCOL DI-P-TOSYLATE;TETRAETHYLENE GLYCOL DITOSYLATE;Tetraethylene glycol di(p-toluenesulfonate);DRAFT CHECKER, AIRFLOW DETECTION POWDER
• CAS NO: 37860-51-8
• Molecular Formula: C₂₂H₃₀O₉S₂
• Molecular Weight: 502.6
• Mol File: 37860-51-8.mol
• Article Data: 114

Chemical Properties

• Melting Point: 65-69 °C
• Boiling Point: 635ºC at 760 mmHg
• Flash Point: >230 °F
• Appearance: colorless to yellow/
• Density: 1.242 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.45E-15mmHg at 25°C
• Refractive Index: n20/D 1.53(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 1610992
• CAS DataBase Reference: TETRAETHYLENE GLYCOL DI-P-TOSYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAETHYLENE GLYCOL DI-P-TOSYLATE(37860-51-8)
• EPA Substance Registry System: TETRAETHYLENE GLYCOL DI-P-TOSYLATE(37860-51-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 37860-51-8(Hazardous Substances Data)

Usage

Description

TETRAETHYLENE GLYCOL DI-P-TOSYLATE, also known as Tos-PEG5-Tos, is a PEG (Polyethylene Glycol) linker containing two tosyl groups. It is characterized by its hydrophilic PEG spacer, which enhances solubility in aqueous media, and the tosyl group, which acts as an excellent leaving group for nucleophilic substitution reactions.

Uses

Used in Chemical Sensing Applications:
TETRAETHYLENE GLYCOL DI-P-TOSYLATE is used as a component in the preparation of donor-spacer-acceptor podand systems, which serve as dual channel fluorosensors for detecting Li+, Mg2+, and Ca2+ ions. The unique properties of the Tos-PEG5-Tos molecule, including its hydrophilic PEG spacer and tosyl leaving group, contribute to the effective detection and differentiation of these ions in various applications.
Used in Chemical Research and Development:
In the field of chemical research and development, TETRAETHYLENE GLYCOL DI-P-TOSYLATE is utilized for its ability to facilitate nucleophilic substitution reactions due to the presence of the tosyl group. This makes it a valuable tool in the synthesis of various chemical compounds and materials.
Used in Pharmaceutical and Biomedical Applications:
The hydrophilic nature of the PEG spacer in TETRAETHYLENE GLYCOL DI-P-TOSYLATE makes it a potential candidate for use in the development of drug delivery systems and other biomedical applications. Its solubility in aqueous media can be advantageous for the design of biocompatible materials and formulations.

InChI:InChI=1/C22H30O9S2/c1-19-3-7-21(8-4-19)32(23,24)30-17-15-28-13-11-27-12-14-29-16-18-31-33(25,26)22-9-5-20(2)6-10-22/h3-10H,11-18H2,1-2H3

Upstream product

• 112-60-7 Tetraethylene glycol 
• 98-59-9 p-toluenesulfonyl chloride 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 

Downstream Products

• 60147-27-5 10,14-bis-(toluene-4-sulfonyl)-1,4,7-trioxa-10,14-diaza-cyclohexadecane 
• 63281-63-0 16-(p-Tolylsulfonyl)-1,4,7,10,13-pentaoxa-16-azacyclooctadecan 
• 60147-30-0 10,13,16-tris(p-tolylsulphonyl)-1,4,7-trioxa-10,13,16-triazacyclo-octadecane 
• 60147-32-2 10,14,18-tris(p-tolylsulphonyl)-1,4,7-trioxa-10,14,18-triazacycloicosane 
• 60147-24-2 10,13-bis-(toluene-4-sulfonyl)-1,4,7-trioxa-10,13-diaza-cyclopentadecane 
• 60147-35-5 10,13,16,19-tetrakis-(toluene-4-sulfonyl)-1,4,7-trioxa-10,13,16,19-tetraaza-cycloheneicosane 
• 83585-51-7 (1,4,7,10,13-Pentaoxa-cyclopentadec-2-ylmethyl)-phenyl-amine 
• 97546-25-3 C₂₄H₂₆O₁₁ 
• 87598-68-3 C₃₀H₄₂O₉ 
• 82264-98-0 3-phenyl-2,4,8,11,14,17,20-heptaoxaspiro<5.15>heneicosane 
• 33089-37-1 24-crown-8 
• 71092-61-0 48-Crown-16 
• 6790-09-6 dodecaethylene glycol 
• 83585-61-9 2-(aminomethyl)-18-crown-6 

Relevant articles and documents

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