97589-52-1

Basic information

• Product Name: N-[(1S)-1-methyl-2-oxo-2-phenylethyl]-2,2,2-trifluoroacetamide
• Synonyms: N-[(1S)-1-methyl-2-oxo-2-phenylethyl]-2,2,2-trifluoroacetamide
• CAS NO: 97589-52-1
• Molecular Weight: 245.201
• Mol File: 97589-52-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[(1S)-1-methyl-2-oxo-2-phenylethyl]-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1S)-1-methyl-2-oxo-2-phenylethyl]-2,2,2-trifluoroacetamide(97589-52-1)
• EPA Substance Registry System: N-[(1S)-1-methyl-2-oxo-2-phenylethyl]-2,2,2-trifluoroacetamide(97589-52-1)

Safety Data

• Hazardous Substances Data: 97589-52-1(Hazardous Substances Data)

Upstream product

• 407-23-8 N-(trifluoroacetyl)-L-alanine 
• 71-43-2 benzene 
• 860800-18-6 N-[(1S)-2-(1H-1,2,3-benzotriazol-1-yl)-1-methyl-2-oxoethyl]-2,2,2-trifluoroacetamide 
• 56271-78-4 (S)-N-trifluoroacetyl-L-alanyl chloride 

Downstream Products

• 62840-99-7 (S)-2--1-phenylpropane 
• 51-64-9 dexamfetamine 

Relevant articles and documents

Synthesis of chiral TFA-protected α-amino aryl-ketone derivatives with friedel-crafts acylation of α-amino acid n-hydroxysuccinimide ester

Chiral N-protected α-amino aryl-ketones are one of the useful precursors used in the synthesis of various biologically active compounds and can be constructed via Friedel-Crafts acylation of N-protected α-amino acids. One of the drawbacks of this reaction

N-(Trifluoroacetyl)-α-amino Acid Chlorides as Chiral Reagents for Friedel-Crafts Synthesis

Chiral N-(trifluoroacetyl)-α-amino acid chlorides unergo Friedel-Crafts reaction with benzene and 1,2-dimethoxybenzene under mild conditions commonly with complete (>99percent) preservation of configurational identity.The resultant (trifluoroacetyl)amino ketones may be deoxygenated with Et3SiH or H2/Pd-C in acidic media to the corresponding N-(trifluoroacetyl)-β-arylalkylamines likewise without loss of configurational purity.