97845-72-2 Usage
Description
6H-Purin-6-one,9-[4-(acetyloxy)-3-[(acetyloxy)methyl]butyl]-2-amino-1,9-dihydrois a complex organic compound with a unique chemical structure. It belongs to the class of purine derivatives and is characterized by the presence of an acetyloxybutyl chain attached to the purine core. This molecule exhibits a wide range of biological activities and has potential applications in various fields.
Uses
Used in Antiviral Applications:
6H-Purin-6-one,9-[4-(acetyloxy)-3-[(acetyloxy)methyl]butyl]-2-amino-1,9-dihydrois used as an antiviral agent for the treatment of viral infections. It is a metabolite of Famciclovir (F101125), a prodrug of Penciclovir (P221500), which is known for its antiviral properties. 6H-Purin-6-one,9-[4-(acetyloxy)-3[(acetyloxy)methyl]butyl]-2-amino-1,9dihydro works by inhibiting viral DNA synthesis and replication, thus helping to control the spread of the virus in the body.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6H-Purin-6-one,9-[4-(acetyloxy)-3-[(acetyloxy)methyl]butyl]-2-amino-1,9-dihydrois used as an active pharmaceutical ingredient (API) for the development of antiviral drugs. Its unique structure and antiviral properties make it a promising candidate for the treatment of various viral diseases, including herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections.
Used in Research and Development:
6H-Purin-6-one,9-[4-(acetyloxy)-3-[(acetyloxy)methyl]butyl]-2-amino-1,9-dihydrois also used in research and development for the study of its potential applications in other therapeutic areas. Scientists are investigating its interactions with various biological targets and exploring its potential as a lead compound for the development of new drugs with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 97845-72-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,8,4 and 5 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 97845-72:
(7*9)+(6*7)+(5*8)+(4*4)+(3*5)+(2*7)+(1*2)=192
192 % 10 = 2
So 97845-72-2 is a valid CAS Registry Number.
97845-72-2Relevant articles and documents
Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides
Derudas, Marco,Vanpouille, Christophe,Carta, Davide,Zicari, Sonia,Andrei, Graciela,Snoeck, Robert,Brancale, Andrea,Margolis, Leonid,Balzarini, Jan,McGuigan, Christopher
supporting information, p. 7876 - 7896 (2017/10/06)
Following our findings on the anti-human immunodeficiency virus (HIV) activity of acyclovir (ACV) phosphate prodrugs, we herein report the ProTide approach applied to a series of acyclic nucleosides aimed at the identification of novel and selective antiv
Practical syntheses of penciclovir and famciclovir from N2-acetyl-7-benzylguanine
Torii, Takayoshi,Shiragami, Hiroshi,Yamashita, Keizo,Suzuki, Yumiko,Hijiya, Toyoto,Kashiwagi, Tatsuki,Izawa, Kunisuke
, p. 5709 - 5716 (2007/10/03)
We have established practical methods for the synthesis of penciclovir (PCV) and famciclovir (FCV) from readily available guanosine via N2-acetyl-7-benzylguanine. The alkylation of N2-acetyl-7-benzylguanine proceeded selectively at the N9 position to give the desired alkylated product in good yield in salt form. After conventional catalytic hydrogenolysis of the benzyl group and hydrolysis of the resulting acetate, pure PCV was obtained without the need for chromatography. As a side chain precursor, the mesylate was selected rather than a halide since the corresponding halides gave several impurities under the same reaction conditions. Two procedures for the synthesis of FCV from PCV and a derivative are also reported.
Antiviral guanine derivatives
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, (2008/06/13)
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