97845-59-5

Basic information

• Product Name: 9H-Purin-2-amine, 6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-
• Synonyms: 5-[2-(2-Amino-6-chloropurin-9-yl)ethyl]-2,2-dimethyl-1,3-dioxane;9H-Purin-2-amine,6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl];2-amino-6-chloro-9-<2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl>purine
• CAS NO: 97845-59-5
• Molecular Formula: C13H18ClN5O2
• Molecular Weight: 311.771
• Mol File: 97845-59-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 9H-Purin-2-amine, 6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Purin-2-amine, 6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-(97845-59-5)
• EPA Substance Registry System: 9H-Purin-2-amine, 6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-(97845-59-5)

Safety Data

• Hazardous Substances Data: 97845-59-5(Hazardous Substances Data)

Upstream product

• 6482-32-2 2-(hydroxymethyl)butane-1,4-diol 

Downstream Products

• 97845-67-5 2-amino-6-(benzyloxy)-9-<4-hydroxy-3-(hydroxymethyl)but-1-yl>purine 
• 104227-86-3 6-deoxypenciclovir 
• 97845-88-0 2-amino-9-<4-hydroxy-3-(hydroxymethyl)but-1-yl>-6-phenoxypurine 
• 97845-78-8 N²-(monomethoxytrityl)-9-<4-hydroxy-3-(hydroxymethyl)but-1-yl>guanine 
• 97845-81-3 9-<4-(benzoyloxy)-3-(hydroxymethyl)but-1-yl>guanine 
• 97845-75-5 9-<4-(formyloxy)-3-<(formyloxy)methyl>but-1-yl>guanine 
• 108970-74-7 9-<4-hydroxy-3-(hydroxymethyl)but-1-yl>xanthine 
• 97845-74-4 9-<4-(hexanoyloxy)-3-<(hexanoyloxy)methyl>but-1-yl>guanine 
• 97845-72-2 2-[(acetyloxy)methyl]-4-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)butyl acetate 
• 206067-84-7 N²-(p-anisyldiphenylmethyl)-9-[(4-(p-toluenesulfonyloxy))-3-p-anisyldiphenylmethoxy-methyl-butyl]guanine 
• 206067-85-8 N²-(p-anisyldiphenylmethyl)-9-[(4-fluoro)-3-p-anisyldiphenylmethoxy-methylbutyl]guanine 
• 97845-77-7 9-(4-hydroxy-3-{[(4-methoxyphenyl)diphenylmethoxy]methyl}butyl)-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one 
• 39809-25-1 Penciclovir 

Relevant articles and documents

An Improved Total Synthesis of PET HSV-tk Gene Reporter Probe 9-(4-[ 18F]Fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG)

An improved total synthesis of [18F]FHBG starting from triethyl-1,1,2-ethanetricarboxylate and 2-amino-6-chloropurine is reported. [18F]FHBG was prepared by nucleophilic substitution of the appropriate precursor with [18F]KF/Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified Silica Sep-Pak solid-phase extraction (SPE) method in 20-25% radiochemical yield.

Novel radiosynthesis of PET HSV-tk gene reporter probes [ 18F]FHPG and [18F]FHBG employing dual Sep-Pak SPE techniques

Positron emission tomography (PET) herpes simplex virus thymidine kinase (HSV-tk) gene reporter probes 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy) methyl]guanine ([18F]FHPG) and 9-(4-[18F]fluoro-3- hydroxymethylbutyl)guanine ([18F]FHBG) were prepared by nucleophilic substitution of the appropriate tosylated precursors with [18F]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified dual Silica Sep-Pak solid-phase extraction (SPE) method in 15-30% radiochemical yield.

AN IMPROVED SYNTHESIS OF THE ANTIVIRAL ACYCLONUCLEOSIDE 9-(4-HYDROXY-3-HYDROXYMETHYLBUT-1-YL)GUANINE

Alkylation of 2-amino-6-chloropurine with 5-(2-bromoethyl)-2,2-dimethyl-1,3-dioxan (7) and subsequent acid hydrolysis provides an improved procedure for synthesis of the antiviral acyclonucleoside 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (3).