206067-85-8

Basic information

• Product Name: N²-(p-anisyldiphenylmethyl)-9-[(4-fluoro)-3-p-anisyldiphenylmethoxy-methylbutyl]guanine
• Synonyms: N²-(p-anisyldiphenylmethyl)-9-[(4-fluoro)-3-p-anisyldiphenylmethoxy-methylbutyl]guanine
• CAS NO: 206067-85-8
• Molecular Weight: 799.945
• Mol File: 206067-85-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N²-(p-anisyldiphenylmethyl)-9-[(4-fluoro)-3-p-anisyldiphenylmethoxy-methylbutyl]guanine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-(p-anisyldiphenylmethyl)-9-[(4-fluoro)-3-p-anisyldiphenylmethoxy-methylbutyl]guanine(206067-85-8)
• EPA Substance Registry System: N²-(p-anisyldiphenylmethyl)-9-[(4-fluoro)-3-p-anisyldiphenylmethoxy-methylbutyl]guanine(206067-85-8)

Safety Data

• Hazardous Substances Data: 206067-85-8(Hazardous Substances Data)

Upstream product

• 206067-84-7 N²-(p-anisyldiphenylmethyl)-9-[(4-(p-toluenesulfonyloxy))-3-p-anisyldiphenylmethoxy-methyl-butyl]guanine 
• 97845-77-7 9-(4-hydroxy-3-{[(4-methoxyphenyl)diphenylmethoxy]methyl}butyl)-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 39809-25-1 Penciclovir 
• 97845-59-5 2-amino-6-chloro-9-<2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl>purine 
• 97845-58-4 5-(2-bromoethyl)-2,2-dimethyl-1,3-dioxane 
• 102147-75-1 2,2-dimethyl-5-(2'-hydroxyethyl)-1,3-dioxane 
• 6482-32-2 2-(hydroxymethyl)butane-1,4-diol 
• 7459-46-3 triethyl 1,1,2-ethanetricarboxylate 

Relevant articles and documents

An Improved Total Synthesis of PET HSV-tk Gene Reporter Probe 9-(4-[ 18F]Fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG)

An improved total synthesis of [18F]FHBG starting from triethyl-1,1,2-ethanetricarboxylate and 2-amino-6-chloropurine is reported. [18F]FHBG was prepared by nucleophilic substitution of the appropriate precursor with [18F]KF/Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified Silica Sep-Pak solid-phase extraction (SPE) method in 20-25% radiochemical yield.

The new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-Fluoropenciclovir)

9-(4-Hydroxy-3-hydroxymethylbutyl) guanine (Penciclovir) is a potent and selective inhibitor of members of the herpes virus family. A new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amin