206067-84-7

Basic information

• Product Name: 6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-
• Synonyms: TOSYL-FHBG;N2-(P-ANISYLDIPHENYLMETHYL)-9-[(4-(P-TOLUOLSULFONYLOXY))-3-P-ANISYLDIPHENYLMETHOXY-METHYLBUTYL]GUANINE;6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-;6H-Purin-6-one, 1,9-dihydro-9-;N2-(p-Anisyldiphenylmethyl)-9-[(4-(p-toluolsulfonyloxy))-3-p-anisyldiphenylmethoxy-methylbutyl]guanin;6H-Purin-6-one, 1,9-dihydro-9- [3-[[(4-methoxyphenyl)diphenylmethoxy]methyl]- 4-[[(4-methylphenyl)sulfonyl]oxy]butyl]- 2-[[(4-methoxyphenyl)diphenylmethyl]amino]-
• CAS NO: 206067-84-7
• Molecular Formula: C₅₇H₅₃N₅O₇S
• Molecular Weight: 952.13
• Mol File: 206067-84-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-(206067-84-7)
• EPA Substance Registry System: 6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-(206067-84-7)

Safety Data

• Hazardous Substances Data: 206067-84-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

Upstream product

• 97845-77-7 9-(4-hydroxy-3-{[(4-methoxyphenyl)diphenylmethoxy]methyl}butyl)-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 39809-25-1 Penciclovir 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 7459-46-3 triethyl 1,1,2-ethanetricarboxylate 
• 6482-32-2 2-(hydroxymethyl)butane-1,4-diol 
• 102147-75-1 2,2-dimethyl-5-(2'-hydroxyethyl)-1,3-dioxane 
• 97845-58-4 5-(2-bromoethyl)-2,2-dimethyl-1,3-dioxane 
• 97845-59-5 2-amino-6-chloro-9-<2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl>purine 

Downstream Products

• 206067-85-8 N²-(p-anisyldiphenylmethyl)-9-[(4-fluoro)-3-p-anisyldiphenylmethoxy-methylbutyl]guanine 
• 718633-31-9 N¹-methyl-N²-(p-anisyldiphenylmethyl)-9-[(4-(p-toluenesulfonyloxy))-3-p-anisyldiphenylmethoxy-methylbutyl]guanine 
• 693260-23-0 9-{3-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-butyl}-2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-1,9-dihydro-purin-6-one 
• 718633-33-1 N¹-methyl-N²-(p-anisyldiphenylmethyl)-9-[(4-fluoro)-3-p-anisyldiphenylmethoxy-methyl-butyl]guanine 

Relevant articles and documents

Efficient synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG)

A new, high radiochemical yield synthesis of [18F]FHBG and [18F]FHPG, the most popular imaging agents currently in use for monitoring gene therapy using positron emission tomography (PET), is reported in this work. Protection of sens

N2S2 chelate-targeting ligand conjugates

The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor ang

An Improved Total Synthesis of PET HSV-tk Gene Reporter Probe 9-(4-[ 18F]Fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG)

An improved total synthesis of [18F]FHBG starting from triethyl-1,1,2-ethanetricarboxylate and 2-amino-6-chloropurine is reported. [18F]FHBG was prepared by nucleophilic substitution of the appropriate precursor with [18F]KF/Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified Silica Sep-Pak solid-phase extraction (SPE) method in 20-25% radiochemical yield.