98383-05-2Relevant articles and documents
Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins
Brown,Kinnick,Morin Jr.,Vasileff,Counter,Davidson,Ensminger,Eudaly,Kasher,Katner,Koehler,Kurz,Lindstrom,Lunn,Preston,Ott,Quay,Shadle,Steinberg,et al.
, p. 2114 - 2121 (1990)
The preparation and biological evaluation of a series of 7β-[2-(2-aminothiazol-4-yl)-2(Z)-methoximinoacetamido]cephalosporins, substituted at the 3'-position with monocyclic or bicyclic nitrogen-containing heterocycles are described. The resulting family of parenteral compounds displays a broad spectrum of antibacterial activity. Some compounds exhibit a similar level of Gram-negative activity to that of the 'third-generation' cephalosporins with increased staphylococcal activity. The in vitro and in vivo antimicrobial activity, structure-activity relationships, β-lactamase stability, and in vitro and in vivo pharmacological evaluations are presented.
