99365-48-7

Basic information

• Product Name: 4-BROMOOXINDOLE
• Synonyms: 4-BROMOOXINDOLE;4-BROMO-2-OXYINDOLE;4-Bromoindolin-2-one;4-Bromo-2-oxindole;4-Bromooxindole ,98%;4-Bromo-2,3-dihydro-1H-indol-2-one;4-Bromo-1,3-dihydro-2H-indol-2-one;4-broMo-1H-indol-1-ol
• CAS NO: 99365-48-7
• Molecular Formula: C₈H₆BrNO
• Molecular Weight: 212.04
• EINECS: 1312995-182-4
• Product Categories: blocks;Bromides;IndolesOxindoles;Indoline & Oxindole
• Mol File: 99365-48-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 202-208
• Boiling Point: 358.2 °C at 760 mmHg
• Flash Point: 170.4 °C
• Appearance: /
• Density: 1.666 g/cm³
• Vapor Pressure: 2.6E-05mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 13.24±0.20(Predicted)
• CAS DataBase Reference: 4-BROMOOXINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOOXINDOLE(99365-48-7)
• EPA Substance Registry System: 4-BROMOOXINDOLE(99365-48-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 99365-48-7(Hazardous Substances Data)

Usage

General Description

4-Bromooxindole is a chemical compound with the molecular formula C8H6BrNO. It is a brominated derivative of oxindole, which is a heterocyclic compound commonly found in natural products and pharmaceuticals. 4-Bromooxindole is used as a building block in organic synthesis and medicinal chemistry, and it has been studied for its potential biological activities, including as an antitumor and antimicrobial agent. Its chemical structure and reactivity make it a valuable tool for the development of new drugs and the investigation of biological processes. Additionally, the bromine atom in 4-bromooxindole makes it useful for various chemical reactions and applications in organic chemistry.

InChI:InChI=1/C8H6BrNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11)

Upstream product

• 37777-74-5 2-(2-bromo-6-nitrophenyl)acetic acid 
• 55289-35-5 2-bromo-6-nitrotoluene 
• 98592-11-1 6-bromo-2-nitrophenylpyruvic acid 
• 603-83-8 3-nitro-o-tolylamine 
• 52488-36-5 4-bromo-1H-indole 
• 1196150-98-7 tert-butyl 4-bromo-2-oxo-2,3-dihydro-1H-indole-1-carboxylate 
• 20780-72-7 4-bromoisatin 

Downstream Products

• 400629-22-3 4-[4-(1-methyl-2-{[methylethylsulfonyl]amino}ethyl)phenyl]indolin-2-one 
• 1172589-06-8 (R)-tert-butyl 2-(2-oxoindolin-4-yl)pyrrolidine-1-carboxylate 
• 1172589-33-1 1‘-benzyl-4-bromo-1,2-dihydrospiro[indole-3,4’-piperidine]-2-one 
• 884855-68-9 4-bromo-1-methyl-1,3-dihydro-2-oxindole 
• 86626-38-2 4-bromo-2,3-dihydro-1H-indole 
• 885272-46-8 tert-butyl 4-bromo-2,3-dihydro-1H-indole-1-carboxylate 
• 1374637-24-7 4'-bromo-2,6-diphenylspiro[cyclohexane-1,3'-indoline]-2',4-dione 
• 214759-51-0 4-cyano-1,3-dihydro-1H-indol-2-one 
• 1637752-37-4 4'-bromospiro[cyclopropane-1,3'-indoline]-2'-one 
• 1172588-54-3 1‘-benzyl-2-oxo-1,2-dihydrospiro[indole-3,4’-piperidine]-4-carbonitrile 
• 1150271-44-5 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 

Relevant articles and documents

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocycl

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The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula (I): or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula (I), including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula (I).