994-89-8 Usage
Description
TRIBUTYLSTANNYLACETYLENE, also known as Ethynyltributylstannane, is an organotin compound with the chemical formula Bu3SnC≡CH. It is a clear colorless liquid and is used as a versatile reagent in organic synthesis.
Uses
Used in Organic Synthesis:
TRIBUTYLSTANNYLACETYLENE is used as an ethynylation reagent for azaaromatics, enabling the formation of various organic compounds.
Used in the Preparation of Vinylstannanes and Stannylisoxazoles:
TRIBUTYLSTANNYLACETYLENE is used as a reactant to prepare vinylstannanes and stannylisoxazoles, which are important intermediates in organic synthesis.
Used in the Synthesis of Terminal Arylacetylene Derivatives:
TRIBUTYLSTANNYLACETYLENE is used in the Stille coupling reaction with aryl halides in the presence of a palladium catalyst to produce terminal arylacetylene derivatives.
Used in the Synthesis of 1,4-bis(tributylstannyl)but-1-yne:
TRIBUTYLSTANNYLACETYLENE is used in the dimerization process using a metal complex with bulky ligand catalyst system to form 1,4-bis(tributylstannyl)but-1-yne.
Used in the Synthesis of Isoquinolone Derivatives:
TRIBUTYLSTANNYLACETYLENE is used in the reaction with benzotriazinones via denitrogenative insertion in the presence of a nickel catalyst to produce isoquinolone derivatives.
Used in the Total Synthesis of (-)-Acutumine and (-)-Dechloroacutumine:
TRIBUTYLSTANNYLACETYLENE is used as an enyne key intermediate in the total synthesis of (-)-acutumine and (-)-dechloroacutumine, which are biologically active compounds.
Purification Methods
Purify it by dissolving the reagent (ca 50g) in heptane (250mL), washing it with H2O (100mL), drying (MgSO4), evaporating and distilling in a vacuum. It has IR: max 3280 ( C), 2950, 2850, 2005 (CC), 1455, 1065 and 865cm-1. [Bottaro et al. J Org Chem 46 5221 1981, Stille & Simpson J Am Chem Soc 109 2138 1987, Zavgorodnii et al. J Gen Chem USSR (Engl Edn) 37 1469 1967.]
Check Digit Verification of cas no
The CAS Registry Mumber 994-89-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,9 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 994-89:
(5*9)+(4*9)+(3*4)+(2*8)+(1*9)=118
118 % 10 = 8
So 994-89-8 is a valid CAS Registry Number.
InChI:InChI=1/3C4H9.C2H.Sn/c3*1-3-4-2;1-2;/h3*1,3-4H2,2H3;1H;/rC14H28Sn/c1-5-9-12-15(8-4,13-10-6-2)14-11-7-3/h4H,5-7,9-14H2,1-3H3
994-89-8Relevant articles and documents
HYDROXAMIC ACID DERIVATIVES AS LPXC INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS
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Page/Page column 103-104, (2014/10/15)
This invention pertains generally to antibacterial organic compounds of Formula I as described herein, and pharmaceutical compositions containing such compounds. In certain aspects, the invention pertains to treating infections caused by Gram-negative bac
FACTOR IXA INHIBITORS
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Page/Page column 80-81, (2014/08/19)
The present invention provides a compound of Formula (I) (structurally represented) wherein R1 is H or C1-6 alkyl, R2 is H or C1-6 alkyl or CH20H, R3 is H or C1-6 alkyl, and R4 is H or C1-6 alkyl, provided that when R1, R2, and R3 are H, R4 is C1-6 alkyl, and when R1, R2, and R4 are H, then R3 is C1-6 alkyl, and when R1, R3, and R4 are H, R2 is C1-6 alkyl or-CH20H, and when R2, R3, and R4 are H, then R1 is C 1-6 alkyl; A is 1 ) a 9-10 membered bicyclic heterocycle having 1-3 heteroatoms independently selected from N, S and 0, which 9-10 membered bicyclic heterocycle is unsubstituted or substituted with R5 and unsubstituted or substituted with R6 and unsubstituted or substituted with NH2, or 2) a 6-9 membered monocyclic or bicyclic carbocyclic ring system unsubstituted or substituted with R5, unsubstituted or substituted with R6, and unsubstituted or substituted with -CH2NH2; and B is 1) a 5- or 6-membered monocyclic heterocycle having 1 or 2 heteroatoms independently selected from N, S or 0, which is unsubstituted or substituted on a carbon or nitrogen atom with R7, unsubstituted or substituted on a carbon or nitrogen atom with R8, and unsubstituted or substituted on a carbon or nitrogen atom with R9, or 2) an 8- or 9-membered fused bicyclic heterocycle having 1, 2 or 3 nitrogen atoms which is unsubstituted or substituted on a carbon or nitrogen atom with R7, and unsubstituted or substituted on a carbon or nitrogen atom with R8; and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses.
6-substituted mycophenolic acid and derivatives
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, (2008/06/13)
The disclosed 6-substituted derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil.
