769-26-6

Basic information

• Product Name: 1-ETHYNYL-2,4,6-TRIMETHYLBENZENE
• Synonyms: 2-ethynyl-1,3,5-trimethylbenzene;2-ethynylmesitylene;benzene,2-ethynyl-1,3,5-trimethyl-;ethynylmesitylene;mesitylacetylene;mesitylene,2-ethynyl-;mesitylethyne;(2,4,6-Trimethylphenyl)acetylene
• CAS NO: 769-26-6
• Molecular Formula: C₁₁H₁₂
• Molecular Weight: 144.21
• Mol File: 769-26-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 2.7-3.5 °C
• Boiling Point: 213.2°Cat760mmHg
• Flash Point: 83℃
• Appearance: /
• Density: 0.921 g/mL at 25 °C
• Vapor Pressure: 0.242mmHg at 25°C
• Refractive Index: n20/D1.547
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-ETHYNYL-2,4,6-TRIMETHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYNYL-2,4,6-TRIMETHYLBENZENE(769-26-6)
• EPA Substance Registry System: 1-ETHYNYL-2,4,6-TRIMETHYLBENZENE(769-26-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 769-26-6(Hazardous Substances Data)

Usage

General Description

1-Ethynyl-2,4,6-trimethylbenzene is a chemical compound with the molecular formula C11H12. It is a colorless liquid with a strong aromatic odor, and it is mainly used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a solvent and as an intermediate in the production of dyes and perfumes. 1-ETHYNYL-2,4,6-TRIMETHYLBENZENE is considered to be of low toxicity, with no known harmful effects on human health or the environment. However, it should be handled with care and proper safety precautions should be taken when working with it.

InChI:InChI=1/C11H12/c1-5-11-9(3)6-8(2)7-10(11)4/h1,6-7H,2-4H3

Upstream product

• 5312-67-4 1-(1-chlorovinyl)-2',4',6'-trimethylbenzene 
• 205311-27-9 2-(1,2-dibromo-ethyl)-1,3,5-trimethyl-benzene 
• 1667-01-2 2,4,6-Trimethylacetophenone 
• 67-56-1 methanol 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 13894-21-8 ethynyl p-tolyl sulfone 
• 4028-63-1 iodomesitylene 
• 994-89-8 tributylethynyltin 
• 88-05-1 2,4,6-trimethylaniline 
• 77295-61-5 1,1-Dibrom-2-(2,4,6-trimethylphenyl)ethylen 
• 487-68-3 mesytaldehyde 
• 1066-54-2 trimethylsilylacetylene 
• 141461-86-1 4-mesityl-2-methylbut-3-yn-2-ol 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 

Downstream Products

• 408511-61-5 2,4,6-trimethyl phenylpropiolic acid 
• 33675-54-6 (2,4,6-trimethylphenyl)ethynyl iodide 
• 858467-44-4 (Ξ)-α,β-dibromo-2,4,6-trimethyl-styrene 
• 22779-25-5 4-[3-(2,4,6-trimethyl-phenyl)-prop-2-ynyl]-morpholine 
• 63124-71-0 (E)-1-Phenyl-5-(2,4,6-trimethylphenyl)-1-penten-4-in-3-ol 
• 54075-63-7 1-Cyclohepta-2,4,6-trienyl-3-(2,4,6-trimethyl-phenyl)-prop-2-yn-1-ol 
• 39231-37-3 1-(triethylsilyl)-4-(2,4,6-trimethylphenyl)-1,3-butadiyne 
• 4493-01-0 1,4-bis(2,4,6-trimethylphenyl)-1,3-butadiyne 
• 33675-49-9 1-Brom-2-(2,4,6-trimethylphenyl)acetylen 
• 91909-20-5 4-(2,4,6-trimethylphenyl)but-3-yn-2-one 
• 24149-00-6 1-Phenyl-3-(2,4,6-trimethyl-phenyl)-propin-1-on-oxim, 3-Mesityl-1-phenyl-propin-1-on-oxim 
• 124234-92-0 3-(2,4,6-Trimethylphenyl)propindithiosaeure-methylester 
• 114819-89-5 1,2,4-trimesitylbenzene 
• 1667-01-2 2,4,6-Trimethylacetophenone 

Relevant articles and documents

The impact of cation structure upon the acidity of triazolium salts in dimethyl sulfoxide

A series of triazolium salts, selected for their varying electronic and steric properties, were prepared and their pKa values were determined in DMSO at 25 °C using the bracketing indicator method. The effect of each systematic structural variation upon the acidity of the triazolium cation has been considered, in particular examining the effects of systematically altering electronic properties, quantified through the use of Hammett σ parameters. The first pKa value for an azolium salt that generates a mesionic carbene is also reported. These new data allow for the selection of appropriate bases for the deprotonation of such triazolium salts and the potential to correlate the pKa values determined herein with the nucleophilicity of the corresponding carbenes.

Gold-Catalyzed Hydrohydrazidation of Terminal Alkynes

Facile gold-catalyzed hydrohydrazidation of alkynes with various hydrazides R2CONHNH2 (R = Alk or Ar; including those with an additional nucleophilic moiety) in the presence of Ph3PAuNTf2 (6 mol %) leading to a wide range of substituted keto-N-acylhydrazones (18 examples) in excellent to good yields (99-66%) is reported. This novel metal-catalyzed coupling proceeds under mild conditions (chlorobenzene, 60 °C), exhibits high functional group tolerance, and is insensitive to the electronic and steric effects of the substituents in the reactants.

Palladium nanoparticles catalyzed Sonogashira reactions for the one-pot synthesis of symmetrical and unsymmetrical diarylacetylenes

A variety of symmetrical and unsymmetrical diarylacetylenes are synthesized by ligand-free palladium nanoparticles catalyzed copper-free and amine-free Sonogashira cross-coupling reactions between aryl iodides and trimethylsilylacetylene (TMSA) under mild reaction conditions.