Loperamide hydrochloride

1.
1.1
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product identifiers
Product name
Product Number
Brand
CAS-No.
:
:
:
:
Loperamide hydrochloride
34014
Fluka
34552-83-5
1.2
Relevant identified uses of the substance or mixture and uses advised against
Identified uses
:
Laboratory chemicals, Manufacture of substances
2.
2.1
2.2
HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute toxicity, Oral (Category 3)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Toxic if swallowed.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word
Hazard statement(s)
H301
Precautionary statement(s)
P301 + P310
Supplemental Hazard
Danger
Toxic if swallowed.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/
physician.
none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R25
S-phrase(s)
S45
Toxic if swallowed.
In case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
2.3
3.
3.1
Other hazards - none
COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Synonyms
Formula
Molecular Weight
Component
:
:
:
4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl- α,α -diphenyl-1-
piperidinebutyramide
C29H33ClN2O2 · HCl
513,50 g/mol
Concentration
4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl- α,α -diphenylpiperidine-1-butyramide
monohydrochloride
CAS-No.
EC-No.
34552-83-5
252-082-4
-
4.
4.1
4.2
4.3
5.
5.1
5.2
5.3
5.4
FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
Nausea, Vomiting, Constipation., Dizziness, fatigue, Central nervous system depression, Gastrointestinal
disturbance, To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available
FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available
6.
6.1
6.2
6.3
6.4
7.
7.1
7.2
7.3
8.
8.1
8.2
ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available
EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
respirators and components tested and approved under appropriate government standards such
as NIOSH (US) or CEN (EU).
9.
9.1
PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a)
b)
c)
d)
e)
f)
g)
h)
Appearance
Odour
Odour Threshold
pH
Melting point/freezing
point
Initial boiling point and
boiling range
Flash point
Evaporation rate
Form: solid
no data available
no data available
no data available
no data available
no data available
no data available
no data available
i)
Flammability (solid, gas) no data available
j)
k)
l)
Upper/lower
flammability or
explosive limits
Vapour pressure
Vapour density
no data available
no data available
no data available
m) Relative density
no data available
n)
o)
p)
q)
r)
s)
t)
Water solubility
Partition coefficient: n-
octanol/water
Autoignition
temperature
Decomposition
temperature
Viscosity
Explosive properties
Oxidizing properties
no data available
no data available
no data available
no data available
no data available
no data available
no data available
9.2
10.
10.1
10.2
10.3
10.4
10.5
10.6
Other safety information
no data available
STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
11.
11.1
TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 185 mg/kg
Remarks: Gastrointestinal:Decreased motility or constipation.
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:
No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Reproductive toxicity - rat - Oral
Effects on Newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4).
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
Ingestion
Skin
Eyes
May be harmful if inhaled. May cause respiratory tract irritation.
Toxic if swallowed.
May be harmful if absorbed through skin. May cause skin irritation.
May cause eye irritation.
Signs and Symptoms of Exposure
Nausea, Vomiting, Constipation., Dizziness, fatigue, Central nervous system depression, Gastrointestinal
disturbance, To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
Additional Information
RTECS: TM4960000
12.
12.1
12.2
12.3
12.4
12.5
ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
12.6
13.
13.1
14.
14.1
Other adverse effects
no data available
DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.
TRANSPORT INFORMATION
UN number
14.2
ADR/RID: 2811
UN proper shipping name
IMDG: 2811
IATA: 2811
ADR/RID:
IMDG:
IATA:
TOXIC SOLID, ORGANIC, N.O.S. (4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl- α,α -
diphenylpiperidine-1-butyramide monohydrochloride)
TOXIC SOLID, ORGANIC, N.O.S. (4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl- α,α -
diphenylpiperidine-1-butyramide monohydrochloride)
Toxic solid, organic, n.o.s. (4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl- α,α -
diphenylpiperidine-1-butyramide monohydrochloride)
14.3
Transport hazard class(es)
14.4
14.5
14.6
15.
ADR/RID: 6.1
Packaging group
ADR/RID: III
Environmental hazards
ADR/RID: no
Special precautions for user
no data available
REGULATORY INFORMATION
IMDG: 6.1
IMDG: III
IMDG Marine pollutant: no
IATA: 6.1
IATA: III
IATA: no
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1
15.2
16.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available
OTHER INFORMATION
Further information
The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. Lookchem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.

;

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