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Chloramphenicol

1.1

IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product identifiers

Product name

Product Number

Brand

CAS-No.

Chloramphenicol

C0378

56-75-7

1.2

Relevant identified uses of the substance or mixture and uses advised against

Identified uses

Laboratory chemicals, Manufacture of substances

2.1

2.2

HAZARDS IDENTIFICATION

Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]

Carcinogenicity (Category 1B)

Classification according to EU Directives 67/548/EEC or 1999/45/EC

May cause cancer.

Label elements

Labelling according Regulation (EC) No 1272/2008 [CLP]

Pictogram

Signal word

Hazard statement(s)

H350

Precautionary statement(s)

P201

P308 + P313

Supplemental Hazard

Statements

Restricted to professional users.

Danger

May cause cancer.

Obtain special instructions before use.

IF exposed or concerned: Get medical advice/ attention.

none

According to European Directive 67/548/EEC as amended.

Hazard symbol(s)

R-phrase(s)

R45

S-phrase(s)

S53

S45

May cause cancer.

Avoid exposure - obtain special instructions before use.

In case of accident or if you feel unwell, seek medical advice immediately

(show the label where possible).

Restricted to professional users.

2.3

3.1

Other hazards - none

COMPOSITION/INFORMATION ON INGREDIENTS

Substances

Synonyms

Formula

Molecular Weight

Component

Chloramphenicol

D-( ? )-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol

Chloromycetin

D-( ? )-threo-2,2-Dichloro-N- [β -hydroxy- α -(hydroxymethyl)- β -(4-

nitrophenyl)ethyl]acetamide

D-threo-2,2-Dichloro-N- [β -hydroxy- α -(hydroxymethyl)-4-

nitrophenethyl]acetamide

C11H12Cl2N2O5

323,13 g/mol

Concentration

CAS-No.

EC-No.

56-75-7

200-287-4

4.1

4.2

4.3

5.1

FIRST AID MEASURES

Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

Nausea, Headache, Vomiting

Indication of any immediate medical attention and special treatment needed

no data available

FIREFIGHTING MEASURES

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2

5.3

5.4

6.1

6.2

6.3

6.4

7.1

7.2

7.3

8.1

8.2

Special hazards arising from the substance or mixture

Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

Further information

no data available

ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure

adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed

containers for disposal.

Reference to other sections

For disposal see section 13.

HANDLING AND STORAGE

Precautions for safe handling

Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use.

Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire

protection.

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Specific end uses

no data available

EXPOSURE CONTROLS/PERSONAL PROTECTION

Control parameters

Components with workplace control parameters

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and

at the end of workday.

Personal protective equipment

Eye/face protection

Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested

and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique

(without touching glove's outer surface) to avoid skin contact with this product. Dispose of

contaminated gloves after use in accordance with applicable laws and good laboratory practices.

Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and

the standard EN 374 derived from it.

Immersion protection

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm

Break through time: > 480 min

Material tested:Dermatril? ( Z677272, Size M)

Splash protection

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm

Break through time: > 30 min

Material tested:Dermatril? ( Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 873000, e-mail sales@kcl.de,

test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374,

contact the supplier of the CE approved gloves. This recommendation is advisory only and must

be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our

customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

impervious clothing, The type of protective equipment must be selected according to the

concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full-face particle

respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering

controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use

respirators and components tested and approved under appropriate government standards such

as NIOSH (US) or CEN (EU).

9.1

PHYSICAL AND CHEMICAL PROPERTIES

Information on basic physical and chemical properties

Appearance

Odour

Odour Threshold

Melting point/freezing

point

Initial boiling point and

boiling range

Flash point

Evaporation rate

Form: crystalline

Colour: light yellow

no data available

149 °C

no data available

Flammability (solid, gas) no data available

Upper/lower

flammability or

explosive limits

Vapour pressure

Vapour density

no data available

m) Relative density

no data available

Water solubility

Partition coefficient: n-

octanol/water

Autoignition

temperature

Decomposition

temperature

practically insoluble

no data available

Viscosity

Explosive properties

Oxidizing properties

no data available

9.2

Other safety information

Solubility in other

solvents

Ethanol

10.

10.1

10.2

10.3

10.4

10.5

10.6

11.

11.1

STABILITY AND REACTIVITY

Reactivity

no data available

Chemical stability

no data available

Possibility of hazardous reactions

no data available

Conditions to avoid

no data available

Incompatible materials

acids, Acid chlorides, Acid anhydrides, Oxidizing agents

Hazardous decomposition products

Other decomposition products - no data available

TOXICOLOGICAL INFORMATION

Information on toxicological effects

Acute toxicity

LD50 Oral - rat - 2.500 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/eye irritation

no data available

Respiratory or skin sensitization

Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals.

Germ cell mutagenicity

Laboratory experiments have shown mutagenic effects.

Genotoxicity in vitro - rat - Liver

DNA damage

Genotoxicity in vivo - mouse - Intraperitoneal

Cytogenetic analysis

Carcinogenicity

This product is or contains a component that has been reported to be probably carcinogenic based on its

IARC, OSHA, ACGIH, NTP, or EPA classification.

Possible human carcinogen

IARC:

2A - Group 2A: Probably carcinogenic to humans (Chloramphenicol)

Reproductive toxicity

no data available

Specific target organ toxicity - single exposure

no data available

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard

no data available

Potential health effects

Inhalation

Ingestion

Skin

Eyes

May be harmful if inhaled. May cause respiratory tract irritation.

May be harmful if swallowed.

May be harmful if absorbed through skin. May cause skin irritation.

May cause eye irritation.

Signs and Symptoms of Exposure

Nausea, Headache, Vomiting

Additional Information

RTECS: AB6825000

12.

12.1

ECOLOGICAL INFORMATION

Toxicity

Toxicity to daphnia and

other aquatic

invertebrates

EC50 - Daphnia magna (Water flea) - 345 mg/l - 48 h

12.2

12.3

12.4

12.5

12.6

13.

13.1

14.

14.1

Persistence and degradability

no data available

Bioaccumulative potential

no data available

Mobility in soil

no data available

Results of PBT and vPvB assessment

no data available

Other adverse effects

no data available

DISPOSAL CONSIDERATIONS

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed

professional waste disposal service to dispose of this material. Dissolve or mix the material with a

combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging

Dispose of as unused product.

TRANSPORT INFORMATION

UN number

ADR/RID: -

14.2

UN proper shipping name

ADR/RID:

Not dangerous goods

IMDG:

Not dangerous goods

IATA:

Not dangerous goods

14.3

Transport hazard class(es)

ADR/RID: -

14.4

Packaging group

ADR/RID: -

IMDG: -

IATA: -

14.5

Environmental hazards

14.6

15.

ADR/RID: no

Special precautions for user

no data available

REGULATORY INFORMATION

IMDG Marine pollutant: no

IATA: no

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1

15.2

16.

Safety, health and environmental regulations/legislation specific for the substance or mixture

no data available

Chemical Safety Assessment

no data available

OTHER INFORMATION

Further information

The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. Lookchem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.

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