Titanium dioxide

1. 1.1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product identifiers Product name Product Number Brand CAS-No. : : : : Titanium(IV) oxide 14021 Anonymous-Anonymous 13463-67-7 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 2. 2.1 2.2 HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Carcinogenicity (Category 2) Classification according to EU Directives 67/548/EEC or 1999/45/EC Limited evidence of a carcinogenic effect. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal word Hazard statement(s) H351 Precautionary statement(s) P281 Supplemental Hazard Warning Suspected of causing cancer. Use personal protective equipment as required. none Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R40 S-phrase(s) S36/37 Limited evidence of a carcinogenic effect. Wear suitable protective clothing and gloves. 2.3 3. 3.1 Other hazards - none COMPOSITION/INFORMATION ON INGREDIENTS Substances Synonyms Formula Molecular Weight Component : : : Titanium dioxide Titania O2Ti 79,87 g/mol Concentration Titanium dioxide, nanoparticles range in size from 1 to 150 nm CAS-No. EC-No. 13463-67-7 236-675-5 - 4. 4.1 4.2 4.3 5. 5.1 5.2 5.3 5.4 FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Indication of any immediate medical attention and special treatment needed no data available FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Special hazards arising from the substance or mixture no data available Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information The product itself does not burn. 6. 6.1 6.2 6.3 6.4 7. 7.1 7.2 7.3 8. 8.1 8.2 ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Specific end uses no data available EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Immersion protection Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: > 480 min Material tested:Dermatril? (Anonymous Z677272, Size M) Splash protection Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: > 30 min Material tested:Dermatril? (Anonymous Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 873000, e-mail sales@kcl.de, test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). 9. 9.1 PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) b) c) d) e) f) g) h) Appearance Odour Odour Threshold pH Melting point/freezing point Initial boiling point and boiling range Flash point Evaporation rate Form: powder Colour: white no data available no data available no data available Melting point/range: > 350 °C no data available no data available no data available i) Flammability (solid, gas) no data available j) k) l) Upper/lower flammability or explosive limits Vapour pressure Vapour density no data available no data available no data available m) Relative density 4,26 g/mL at 25 °C n) o) p) q) r) s) t) Water solubility Partition coefficient: n- octanol/water Autoignition temperature Decomposition temperature Viscosity Explosive properties Oxidizing properties no data available no data available no data available no data available no data available no data available no data available 9.2 Other safety information no data available 10. 10.1 10.2 10.3 10.4 10.5 10.6 11. 11.1 STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong acids Hazardous decomposition products Other decomposition products - no data available TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity LD50 Oral - rat - > 10.000 mg/kg LD50 Dermal - rabbit - > 10.000 mg/kg Skin corrosion/irritation Skin - Human - Mild skin irritation - 3 h Serious eye damage/eye irritation Eyes - rabbit - No eye irritation Respiratory or skin sensitization Will not occur Germ cell mutagenicity Genotoxicity in vitro - Hamster - ovary Micronucleus test Genotoxicity in vitro - Hamster - Lungs DNA inhibition Genotoxicity in vitro - Hamster - ovary Sister chromatid exchange Genotoxicity in vivo - mouse - Intraperitoneal Micronucleus test Carcinogenicity Suspected human carcinogens IARC: 2B - Group 2B: Possibly carcinogenic to humans (Titanium dioxide, nanoparticles range in size from 1 to 150 nm) Reproductive toxicity Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects Inhalation Ingestion Skin Eyes May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if swallowed. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. Signs and Symptoms of Exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Additional Information RTECS: Not available 12. 12.1 ECOLOGICAL INFORMATION Toxicity Toxicity to fish Toxicity to daphnia and LC50 - other fish - > 1.000 mg/l - 96 h EC50 - Daphnia magna (Water flea) - > 1.000 mg/l - 48 h other aquatic invertebrates EC0 - Daphnia magna (Water flea) - 1.000 mg/l - 48 h 12.2 12.3 12.4 12.5 12.6 13. 13.1 14. 14.1 Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. TRANSPORT INFORMATION UN number ADR/RID: - 14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods 14.3 Transport hazard class(es) ADR/RID: - 14.4 Packaging group ADR/RID: - 14.5 Environmental hazards ADR/RID: no 14.6 Special precautions for user no data available IMDG: - IMDG: - IMDG: - IMDG Marine pollutant: no IATA: - IATA: - IATA: - IATA: no 15. 15.1 15.2 16. REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment no data available OTHER INFORMATION Further information The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Lookchem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.

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