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Ethisterone

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name

Ethisterone

2. HAZARDS IDENTIFICATION

Classification of the substance or mixture

According to Regulation (EC) No1272/2008

Reproductive toxicity (Category 1A)

According to European Directive 67/548/EEC as amended.

May cause harm to the unborn child.

Label elements

Pictogram

Signal word

Hazard statement(s)

Precautionary statement(s)

Hazard symbol(s)

R-phrase(s)

R61

S-phrase(s)

S53

S45

Danger

none

Toxic

May cause harm to the unborn child.

Avoid exposure - obtain special instructions before use.

In case of accident or if you feel unwell, seek medical advice immediately

(show the label where possible).

Restricted to professional users.

Other hazards - none

3. COMPOSITION/INFORMATION ON INGREDIENTS

Synonyms

Formula

Molecular Weight

17α -Ethynyltestosterone

17β -Hydroxy- 4,17α -pregnen-20-yn-3-one

4,17α -Pregnen- 17β -ol-20-yn-3-one

C21H28O2

312,45 g/mol

CAS-No.

EC-No.

Classification

Concentration

Ethisterone

434-03-7

207-096-5

Repr. 1A;

T, R61

For the full text of the H-Statements mentioned in this Section, see Section 16.

4. FIRST AID MEASURES

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

5. FIRE-FIGHTING MEASURES

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special protective equipment for fire-fighters

Wear self contained breathing apparatus for fire fighting if necessary.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions

Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure

adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed

containers for disposal.

7. HANDLING AND STORAGE

Precautions for safe handling

Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use.

Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire

protection.

Conditions for safe storage

Keep container tightly closed in a dry and well-ventilated place. Store in cool place.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Personal protective equipment

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator

type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the

respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and

components tested and approved under appropriate government standards such as NIOSH (US) or CEN

(EU).

Hand protection

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the

standard EN 374 derived from it.

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without

touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves

after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Eye protection

Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and

approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin and body protection

impervious clothing, The type of protective equipment must be selected according to the concentration

and amount of the dangerous substance at the specific workplace.

Hygiene measures

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at

the end of workday.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance

Form

Colour

Safety data

Melting point

Boiling point

Flash point

Ignition temperature

Lower explosion limit

Upper explosion limit

Water solubility

crystalline, powder

white

no data available

263 - 269 °C

no data available

soluble

10. STABILITY AND REACTIVITY

Chemical stability

Stable under recommended storage conditions.

Conditions to avoid

no data available

Materials to avoid

Strong oxidizing agentsStrong oxidizing agents

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides

11. TOXICOLOGICAL INFORMATION

Acute toxicity

no data available

Skin corrosion/irritation

no data available

Serious eye damage/eye irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as

probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

Reproductive toxicity - rat - Oral

Effects on Fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per

# estrus cycles).

Reproductive toxicity - rat - Oral

Paternal Effects: Prostate, seminal vessicle, Cowper's gland, accessory glands.

Known human reproductive toxicant

Developmental Toxicity - Human - female - Oral

Specific Developmental Abnormalities: Urogenital system.

Developmental Toxicity - rat - Oral

Specific Developmental Abnormalities: Urogenital system.

Specific target organ toxicity - single exposure

no data available

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard

no data available

Potential health effects

Inhalation

Ingestion

Skin

Eyes

May be harmful if inhaled. May cause respiratory tract irritation.

May be harmful if swallowed.

May be harmful if absorbed through skin. May cause skin irritation.

May cause eye irritation.

Signs and Symptoms of Exposure

Electrolyte imbalance.

Additional Information

RTECS: TU5570250

12. ECOLOGICAL INFORMATION

Toxicity

no data available

Persistence and degradability

no data available

Bioaccumulative potential

no data available

Mobility in soil

no data available

PBT and vPvB assessment

no data available

Other adverse effects

no data available

13. DISPOSAL CONSIDERATIONS

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional

waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent

and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging

Dispose of as unused product.

14. TRANSPORT INFORMATION

ADR/RID

Not dangerous goods

IMDG

Not dangerous goods

IATA

Not dangerous goods

15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

16. OTHER INFORMATION

Text of H-code(s) and R-phrase(s) mentioned in Section 3

Repr.

R61

Reproductive toxicity

Toxic

May cause harm to the unborn child.

Further information

The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. Lookchem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.

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