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L-Tryptophan

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name

L-Tryptophan

2. HAZARDS IDENTIFICATION

Classification of the substance or mixture

Not a dangerous substance according to GHS.

This substance is not classified as dangerous according to Directive 67/548/EEC.

Label elements

The product does not need to be labelled in accordance with EC directives or respective national laws.

Other hazards - none

3. COMPOSITION/INFORMATION ON INGREDIENTS

Synonyms

Formula

Molecular Weight

L- α -Amino-3-indolepropionic acid

(S)-2-Amino-3-(3-indolyl)propionic acid

C11H12N2O2

204,23 g/mol

CAS-No.

EC-No.

Classification

Concentration

L-Tryptophan

73-22-3

200-795-6

4. FIRST AID MEASURES

If inhaled

If breathed in, move person into fresh air. If not breathing give artificial respiration

In case of skin contact

Wash off with soap and plenty of water.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water.

5. FIRE-FIGHTING MEASURES

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special protective equipment for fire-fighters

Wear self contained breathing apparatus for fire fighting if necessary.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions

Avoid dust formation.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Sweep up and shovel. Keep in suitable, closed containers for disposal.

7. HANDLING AND STORAGE

Precautions for safe handling

Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire

protection.

Conditions for safe storage

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Light sensitive. Moisture sensitive. Store under inert gas.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Personal protective equipment

Respiratory protection

Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use

type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved

under appropriate government standards such as NIOSH (US) or CEN (EU).

Hand protection

For prolonged or repeated contact use protective gloves.

Eye protection

Safety glasses

Hygiene measures

General industrial hygiene practice.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance

Form

Colour

Safety data

Melting point

Boiling point

Flash point

Ignition temperature

Lower explosion limit

Upper explosion limit

Water solubility

crystalline

white

no data available

280 - 285 °C

no data available

10. STABILITY AND REACTIVITY

Chemical stability

Stable under recommended storage conditions.

Conditions to avoid

no data available

Materials to avoid

Strong oxidizing agents

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx)

11. TOXICOLOGICAL INFORMATION

Acute toxicity

LD50 Oral - rat - > 16.000 mg/kg

Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Ptosis. Behavioral:Coma.

Nutritional and Gross Metabolic:Changes in:Body temperature decrease.

Skin corrosion/irritation

no data available

Serious eye damage/eye irritation

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as

probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

Specific target organ toxicity - single exposure

Specific target organ toxicity - repeated exposure

Aspiration hazard

Potential health effects

Inhalation

Ingestion

Skin

Eyes

May be harmful if inhaled. May cause respiratory tract irritation.

May be harmful if swallowed.

May be harmful if absorbed through skin. May cause skin irritation.

May cause eye irritation.

Signs and Symptoms of Exposure

The Food and Drug Administration and the Center for Disease Control have established a link between l-

tryptophan and a sometimes fatal blood disorder called eosinophilia-myalgia syndrome which is marked by

severe muscle and joint pain, swelling of the arms and legs, skin rash, and sometimes fever. It is characterized

by severe eosinophillia, a blood disorder in which the white blood cells increase to an abnormally high level. l-

Tryptophan occurs naturally in many foods and investigation has not established whether it or an impurity

introduced during manufacture or distribution is the cause.

Additional Information

RTECS: YN6130000

12. ECOLOGICAL INFORMATION

Toxicity

no data available

Persistence and degradability

no data available

Bioaccumulative potential

Mobility in soil

PBT and vPvB assessment

no data available

Other adverse effects

no data available

13. DISPOSAL CONSIDERATIONS

Product

Observe all federal, state, and local environmental regulations.

Contaminated packaging

Dispose of as unused product.

14. TRANSPORT INFORMATION

ADR/RID

Not dangerous goods

IMDG

Not dangerous goods

IATA

Not dangerous goods

15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

16. OTHER INFORMATION

Further information

The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. Lookchem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.

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