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Polymyxin B sulfate

03/17/2004 16 :38 2625131079 EMP BURROUGHS WELLCOME ; -- NEOSPORIN PRODUCTS

BURROUGHS WELLCOME -- NEOSPORIN PRODUCTS
MATERIAL SAFETY DATA SHEET
NSN : 6505011434644
Manufacturer's CAGE : 09979
Part No . Indicator : A
Part Number/Trade Name : NEOSPORIN PRODUCTS
-------------------------
General Information

Company's Name : BURROUGHS WELLCOME CO
Company's Street : INTERSECTION US 13 AND S R 1590
Company's P . 0 . Box : 1887
Company's City : GREENVILLE
Company's State : NC
Company's Country ; US
Company's Zip Code : 27835-1887
Company's Emerg Ph # : 919-758-3436
Company's info Ph # : 919-758-3436
Record No . For Safety Entry : 001
Tot Safety Entries This Stk# : 001
Status : SE
Date MSDS Prepared : 31OCT94
Safety Data Review Date : 26MAY95
Preparer's Company : BURROUGHS WELLCOME CO
Preparer's St Or P . 0 . Box : INTERSECTION US 13 AND S R 1590
Preparer's City : GREENVILLE
Preparer's State : NC
Preparer's Zip Code : 27835-1887
MSDS Serial Number : BXNZ -------------------------------
Ingredients/Identity Information

Proprietary : NO
Ingredient : POLYMYXIN B SULFATE
Ingredient Sequence Number : 01
NIOSH (RTECS) Number : TR1150000
CAS Number : 1405-20-5
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Proprietary : NO
Ingredient : NEOMYCIN SULFATE
Ingredient Sequence Number : 02
NIOSH (RTECS) Number : QP4375000
CAS Number : 1405-10-3
-------------------------------------
Proprietary : NO
Ingredient : BACITRACIN
Ingredient Sequence Number : 03
NIOSH (RTECS) Number : CP0175000
CAS Number ; 1405-87-4
-------------------------------------
Proprietary : NO
Ingredient : LIDOCAINE (BASE)
Ingredient Sequence Number : 04
NIOSH (RTECS) Number : AN7525000
CAS Number : 137-58-6
Physical/Chemical Characteristics

Appearance And Odor : REFER TO PRODUCT LABEL/INSERT FOR SPECIFIC PRODUCT
DESCRIPTION

Fire and Explosion Hazard Data

11/12/01
http ://msds .pdc .corneU .edu/msds/siri/msds/h/g343/g337 .btml

EMP 03/17/2004 16 :38 2625131079
BURROUGHS WELLCOME -- NEOSPORIN PRODUCTS

Extinguishing Media : USE AGENT APPROPRIATE TO NATURE OF FIRE & OTHE MATERIALS INVOLVED .
Special Fire Fighting Proc : WEAR SELF CONTAINED BREATHING APPARATUS .

Reactivity Data

Stability : YES
Hazardous Decomp Products ; TOXIC/IRRITANT FUMES .
Hazardous Poly Occur : NO

Health Hazard Data

LD50-LC50 Mixture : ORAL LDSO (MOUSE) ; 8 MG/KG (SEE SUPP)
Route Of Entry - Inhalation : YES
Route Of Entry - Skin ; NO
Route Of Entry - Ingestion : YES
Health Haz Acute And Chronic : POLYMYXIN B SULFATE-NEUROTOXICITY/
NEPHROTOXICITY/NEUROMUSCULAR BLOCKADE/SYSTEMIC POLYMYXIN POISONING/KIDNEY
DAMAGE/SENSITIZATION . NEOMYCIN SULFATE-HYPERSENSITIVITY REACTIONS/SEVERE
RENAL TOXICITY/NEUROTOXICITY/OTOTOXICITY/NEUROMUSCULAR BLOCKADE/RESPIRATORY
PARALYSIS . BACITRACIN ZINC-IRRITATION/ALLERGIC REACTIONS (SUPP)
Carcinogenicity - NTP : NO
Carcinogenicity - IARC : NO
Carcinogenicity - OSHA : NO
Explanation Carcinogenicity : NONE
Signs/Symptoms Of Overexp : POLYMYXIN B SULFATE-FEVER . NEOMYCIN SULFATE-
RASH, HEARING LOSS, DIMINISHED BALANCE . BACITRACIN ZINC-IRRITATION .
LIDOCAINE-IRRITATION .
Emergency/First Aid Proc : EYES : RINSE IMMEDIATELY W/PLENTY OF WATER .
INHALATION : REMOVE TO FRESH AIR- KEEP WARM & QUIET . GIVE CPR IF NEEDED .
INGESTION : WASH OUT MOUTH . GIVE PLENTY OF WATER/BLAND FLUIDS . UNLESS
VOMITING IS COPIOUS, LAVAGE SHOULD BE CARRIED OUT- SKIN : WASH OFF W/PLENTY
OF WATER . OBTAIN MEDICAL ATTENTION IN ALL CASES .

for Safe Handling and Use
Precautions

Steps if Matl Released/Spill : WIPE/MOP UP MATERIAL . WASH ALL CONTAMINA'T'E SURFACES W/SOAP & WATER . PLACE WASTE IN APPROPRIATE CONTAINER FOR DISPOSAL .
Waste Disposal Method : DISPOSE OF IAW/FEDERAL, STATE & LOCAL REGULATIONS .
Precautions-Handling/Storing : STORE IN ORIGINAL CONTAINER TIGHTLY CLOSED .
Other Precautions : AVOID SKIN & EYE CONTACT .

Control Measures

Respiratory Protection ; NONE NECESSARY .
Ventilation : NONE NECESSARY .
Protective Gloves : LATEX
Work Hygienic Practices : REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE .
Suppl . Safety & Health Data : ORAL LD50 INFORMATION IS FOR POLYMYXIN B
SULFATE . HEALTH HAZARDS CONT'D : NEPHROTOXICITY . LIDOCAINE-EYE/SKIN/
RESPIRATORY TRACT IRRITATION, TOPICAL ANESTHESIA . INGESTION IS TOXIC .
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Transportation Data

Disposal Data

Label Data

Label Required : YES
Label Status : G
Common Name : NEOSPORIN PRODUCTS

11/12101
http ://msds .pdc .corneU .edu/msds/siri/msds/h/g343/g337 .html

03/17/2004 16 :38 2625131079 EMP BURROUGHS WELLCOME -- NEOSPORIN PRODUCTS

Special Hazard Precautions : POLYMYXIN B SULFATE-NEUROTOXICITY/
NEPHROTOXICITY/NEUROMUSCULAR BLOCKADE/SYSTEMIC POLYMYXIN POISONING/KIDNEY
DAMAGE/SENSITIZATION . NEOMYCIN SULFATE-HYPERSENSITIVITY REACTIONS/SEVERE
RENAL TOXICITY/NEUROTOXICITY/OTOTOXICITY/NEUROMUSCULAR BLOCKADE/RESPIRATORY
PARALYSIS . BACITRACIN ZINC-IRRITATION/ALLERGIC REACTIONS (SUPP)POLYMYX : :N ]B
SULFATE-FEVER . NEOMYCIN SULFATE-RASH, HEARING LOSS, DIMINISHED BALANCE
BACITRACIN ZINC-IRRITATION . LIDOCAINE-IRRITATION .
Label Name : BURROUGHS WELLCOME CO
Label Street : INTERSECTION US 13 AND S R 1590
Label P .O . Box : 1887
Label City : GREENVILLE
Label State : NC
Label Zip Code : 27835-1887
Label Country : US
Label Emergency Number : 919-758-3436

11/12/01
http ://msds .pdc.comell .edu/msds/siri/msds/h/g343/g337 .html

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