1,4-Benzenediol,2-(methylnitrosoamino)-

SAFETY DATA SHEET (MSDS)
August 31, 2001
Date of Preparation or Revision:

IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY:
Catalog Number: 539616
Product Name: Protein Phosphatase Inhibitor Set
CALBIOCHEM?
Supplier:
P.O. Box 12087
La Jolla, CA 92039-2087
Telephone: (858) 450-5558
(800) 854-3417
Fax: (858) 453-3552
CHEMTREC?
Emergency Contact:
(800) 424-9300 (within U.S.A.)
(703) 527-3887 (outside U.S.A.)

COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: Protein Phosphatase Inhibitor Set
Hazardous Ingredients: Cypermethrin 10 mg
10 ??g
Okadaic Acid
25 ??g
Tautomycin
CAS Registry Numbers: 52315-07-8 Cypermethrin
151606-30-3 Dephostatin
78111-17-8 Okadaic Acid
109946-35-2 Tautomycin

HAZARDOUS IDENTIFICATION:
Cypermethrin: May be toxic by ingestion. Material may cause irritation to the eyes and skin. Exposure
to material may cause the following: stinging or burning sensation on the skin, tingling and numbness,
nausea, vomiting, diarrhea, headache, dizziness, fatigue, convulsions, unconsciousness, and coma.
Material may be fatal due to respiratory failure.
Okadaic Acid: May be toxic ingestion, inhalation or absorption through skin. Material may cause
irritation to the skin. Exposure to material may cause the following: diarrhea, stomach pains, and
nausea. Material may cause marked contractile effects on smooth muscles and cardiac muscles.
Tautomycin: May be highly toxic by ingestion, inhalation or absorption through skin. Material is a
potent inhibitor of protein phosphatases and may cause smooth muscle contraction.

FIRST AID MEASURES:
In cases of skin contact, wash immediately with copious amounts of water for at least 15 minutes.
Remove contaminated clothing and shoes and wash before wearing. Consult a physician.
In cases of eye contact, flush immediately with copious amounts of water for at least 15 minutes.
Assure adequate flushing by separating the eyelids with fingers. Consult a physician.
In cases of inhalation, remove to fresh air and monitor breathing. If breathing becomes difficult, give
oxygen and consult a physician. If breathing stops, give artificial respiration and consult a physician.
In cases of ingestion, wash mouth out with water and consult the local poison center and a physician.

FIRE-FIGHTING MEASURE:


539616, Rev. 08-31-01
 Extinguishing Media: Dry chemical powder, carbon dioxide, water spray, alcohol or polymer foam.
Special Fire Fighting Procedures: Wear self-contained breathing apparatus and full protective clothing
to prevent contact with skin and eyes.
Unusual Fire and Explosive Hazards: Upon thermal decomposition, it may EMIT TOXIC GASES.

ACCIDENTAL RELEASE MEASURES:
Steps to be Taken if Material is Released or Spilled: Evacuate area. Wear a self-contained breathing
apparatus, rubber boots, and heavy rubber gloves. Sweep up and place in a suitable container. Avoid
raising dust. Hold for appropriate disposal. Wash spill site and ventilate area after material pickup is
complete.

HANDLING AND STORAGE:
Store in a tightly closed container in a -20??C freezer. Protect from light and moisture. Material is highly
toxic and an irritant. Avoid contact with material. Avoid prolonged or repeated exposure. Lab should
be equipped with a safety shower and an eye wash station. Wash thoroughly after handling material.

EXPOSURE CONTROLS/PERSONAL PROTECTION:
Protective Equipment: Wear suitable protective clothing, such as chemical resistant gloves and
chemical safety goggles.
Respiratory Protection and Ventilation: Use a NIOSH/MSHA approved respirator. Handle in a
chemical fume hood with adequate ventilation.

PHYSICAL AND CHEMICAL PROPERTIES:
Kit Components: Cypermethrin 10 mg
Dephostatin 1 mg
10 ??g
Okadaic Acid
25 ??g
Tautomycin
Flash Point: N/A

STABILITY AND REACTIVITY:
Stability: Stable under normal handling procedures.
Incompatibilities and Conditions to Avoid: Avoid contact with strong oxidizing agents.
Hazardous Combustion or Decomposition Products: Upon thermal decomposition, may emit toxic
gases including carbon monoxide, carbon dioxide, nitrogen oxides, and hydrogen chloride gas.

TOXICOLOGICAL INFORMATION:
RTECS Number: GZ1250000 (Cypermethrin)

Toxicity Data and References:
Ihl; rat; LC50: 7889 mg/m3/4H 1985. Defense des Vegetaux. 39(236), 3.
Orl; rat; LD50: 57500 ??g/kg Somnolence, convulsions and changes in structure or function of
salivary glands 1990. Journal of Environmental Biology. 11, 331.
Orl; mus; LD50: 24570 ??g/kg Somnolence, convulsions and changes in structure or function
of salivary glands 1990. Journal of Environmental Biology. 11, 331.
Orl; rbt; LD50: 1500 mg/kg Somnolence, convulsions and changes in structure or function
of salivary glands 1990. Journal of Environmental Biology. 11, 331.
Orl; gpg; LD50: 500 mg/kg 1980. Defense des Vegetaux. 34, 3.
Orl; ham; LD50: 400 mg/kg 1980. Defense des Vegetaux. 34, 3.
Skn; rat; LD50: >1600 mg/kg 1984. ??Agrochemicals Handbook.?? A110.
Skn; rbt; LD50: >2400 mg/kg 1991. Pesticide Manual. 9, 208.
Skn; mam; LD50: 2355 mg/kg 1991. Gigiena i Sanitariya. For English translation, see
HYSAAV. 56(4), 83.

Reproductive Effects and References:
539616, Rev. 08-31-01
 Ipr; mus; Dose: 30 mg/kg Toxic effects on spermatogenesis 1988. Toxicology Letters. 41,
223.
Unr; rat; Dose: 400 mg/kg Fetotoxicity 1984. Gigiena i Sanitariya. For English translation,
see HYSAAV. 49(10), 70.


Genetic Data and References:
Lym; hmn; Dose: 67 ??mol/l DNA inhibition 1987. Drug and Chemical Toxicology. 10, 291.
Orl; mus; Dose: 50 mg/kg Cytogenetic analysis 1988. Toxicology Letters. 41, 223.
Lym; hmn; Dose: 200 mg/L Micronucleus test 1995. Mutation Research. 341, 169.
Orl; mus; Dose: 756 mg/kg/7D-C Micronucleus test 1985. Mutation Research. 155, 135.
Skn; mus; Dose: 2520 mg/kg/7D-C Micronucleus test 1985. Mutation Research. 155, 135.
Ipr; mus; Dose: 30 mg/kg/4D-C Sperm morphology 1988. Toxicology Letters. 41, 223.

Standards and Regulations:
EPA FIFRA 1988 Pesticide Subject to Registration or Re-registration 1989. Federal Register.
54, 7740.

RTECS Number: CZ9021800 (Dephostatin)

Toxicity Data and References:
Ipr; mus; LD50: >100 mg/kg 1993. Journal of Antibiotics. 46, 1342.

RTECS Number: AA8227800 (Okadaic Acid)

Toxicity Data and References:
Ipr; mus; LD50: 192 ??g/kg 1981. Journal of the American Chemical Society. 103, 2469.*

Genetic Data and References:
Lng; ham; Dose: 10 ??g/l Mutations in mammalian somatic cells 1991. Mutation Research.
250, 375.*
Lym; hmn; Dose: 3800 ??mol/l Sister chromatid exchange 1993. Mutation Research. 289,
275.*
Ovr; hmn; Dose: 2500 ??mol/l Sister chromatid exchange 1993. Mutation Research. 289,
275.*

Tumorigenic Data and References:
Skn; mus; Dose: 12 mg/kg/30W-I Skin and appendage tumors 1988. Japanese Journal of
Cancer Research. 79, 1089.

RTECS Number: WX1000000 (Tautomycin)

Toxicity Data and References:
Ipr; mus; LD50: 5 mg/kg 1987. Journal of Antibiotics. 40, 907.
Orl; mus; LD50: 7500 ??g/kg 1987. Journal of Antibiotics. 40, 907.

Genetic Data and References:
Leu; hmn; Dose: 1 mg/l Morphological transformation 1988. Journal of Antibiotics. 41, 932.

Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for a definition of abbreviations
used in the above text and for additional information. This report contains only selected information
from the RTECS.

ECOLOGICAL INFORMATION:
539616, Rev. 08-31-01
 No information available.

DISPOSAL CONSIDERATIONS:
Country, federal, state, and local regulations are varied and change frequently. For this reason, we
recommend that you contact your local Department of Health Services for information on the disposal
of this product or arrange for disposal by a licensed disposal company.

TRANSPORTATION INFORMATION:
UN Number: UN2811
Proper Shipping Name: Toxic solid, organic, n.o.s.*
IATA Class: 6.1
IATA Packing Group: II

REGULATORY INFORMATION: T+
Risk Phrases:
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.
R36/38: Irritating to eyes and skin.

Safety Phrases:
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek
medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately.

OTHER INFORMATION:
Avoid contact with material. Avoid prolonged or repeated exposure. Wash thoroughly after handling.
Material should only be handled by qualified, experienced professionals. The above information is
believed to be correct but does not purport to be all inclusive and shall be used only as a guide for
experienced personnel. CALBIOCHEM-NOVABIOCHEM Corporation shall not be held liable for any
damage resulting from the handling or from contact with the above product. See reverse side of
invoice or packing slip for additional terms and conditions of sale.




539616, Rev. 08-31-01

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