information Related products Suppliers

Vincristine sulfate

1.1

IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product identifiers

Product name

Product Number

Brand

CAS-No.

Vincristine sulfate

V8388

Anonymous-Anonymous

2068-78-2

1.2

Relevant identified uses of the substance or mixture and uses advised against

Identified uses

Laboratory chemicals, Manufacture of substances

2.1

2.2

HAZARDS IDENTIFICATION

Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]

Acute toxicity, Oral (Category 2)

Germ cell mutagenicity (Category 2)

Reproductive toxicity (Category 2)

Classification according to EU Directives 67/548/EEC or 1999/45/EC

Toxic if swallowed. Possible risk of impaired fertility. Possible risk of harm to the unborn child. Possible risk

of irreversible effects.

Label elements

Labelling according Regulation (EC) No 1272/2008 [CLP]

Pictogram

Signal word

Hazard statement(s)

H300

H341

H361fd

Precautionary statement(s)

P264

P281

P301 + P310

Danger

Fatal if swallowed.

Suspected of causing genetic defects.

Suspected of damaging fertility. Suspected of damaging the unborn child.

Wash hands thoroughly after handling.

Use personal protective equipment as required.

IF SWALLOWED: Immediately call a POISON CENTER or doctor/

physician.

Supplemental Hazard

none

Statements

According to European Directive 67/548/EEC as amended.

Hazard symbol(s)

R-phrase(s)

R25

R62

R63

R68

S-phrase(s)

S36/37

S45

Toxic if swallowed.

Possible risk of impaired fertility.

Possible risk of harm to the unborn child.

Possible risk of irreversible effects.

Wear suitable protective clothing and gloves.

In case of accident or if you feel unwell, seek medical advice immediately

(show the label where possible).

2.3

3.1

Other hazards - none

COMPOSITION/INFORMATION ON INGREDIENTS

Substances

Synonyms

Formula

Molecular Weight

Component

Vincristine sulphate

Vincristinesulfate salt

VCR

Leurocristinesulfate salt

22-Oxovincaleukoblastinesulfate salt

C46H56N4O10 · H2SO4

923,04 g/mol

Concentration

CAS-No.

EC-No.

2068-78-2

218-190-0

4.1

4.2

4.3

FIRST AID MEASURES

Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

Effects due to ingestion may include:, peripheral neuropathy, constipation, Alopecia.

Indication of any immediate medical attention and special treatment needed

no data available

5.1

5.2

5.3

5.4

6.1

6.2

6.3

6.4

7.1

7.2

7.3

8.1

8.2

FIREFIGHTING MEASURES

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides, nitrogen oxides (NOx), Sulphur oxides

Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

Further information

no data available

ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate

ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed

containers for disposal.

Reference to other sections

For disposal see section 13.

HANDLING AND STORAGE

Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols.

Provide appropriate exhaust ventilation at places where dust is formed.

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Recommended storage temperature: -20 °C

Product is sensitive to light and moisture.

Specific end uses

no data available

EXPOSURE CONTROLS/PERSONAL PROTECTION

Control parameters

Components with workplace control parameters

Exposure controls

Appropriate engineering controls

Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling

the product.

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under

appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique

(without touching glove's outer surface) to avoid skin contact with this product. Dispose of

contaminated gloves after use in accordance with applicable laws and good laboratory practices.

Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and

the standard EN 374 derived from it.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected

according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full-face particle

respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering

controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use

respirators and components tested and approved under appropriate government standards such

as NIOSH (US) or CEN (EU).

9.1

PHYSICAL AND CHEMICAL PROPERTIES

Information on basic physical and chemical properties

Appearance

Odour

Odour Threshold

Melting point/freezing

point

Initial boiling point and

boiling range

Flash point

Evaporation rate

Form: powder

Colour: white

no data available

Melting point/range: 300 °C

no data available

Flammability (solid, gas) no data available

Upper/lower

flammability or

explosive limits

Vapour pressure

Vapour density

no data available

m) Relative density

no data available

Water solubility

Partition coefficient: n-

octanol/water

Autoignition

temperature

Decomposition

temperature

Viscosity

Explosive properties

Oxidizing properties

no data available

9.2

Other safety information

no data available

10.

10.1

10.2

10.3

10.4

10.5

10.6

11.

11.1

STABILITY AND REACTIVITY

Reactivity

no data available

Chemical stability

no data available

Possibility of hazardous reactions

no data available

Conditions to avoid

Avoid moisture.

Incompatible materials

Strong oxidizing agents, Heavy metal salts

Hazardous decomposition products

Other decomposition products - no data available

TOXICOLOGICAL INFORMATION

Information on toxicological effects

Acute toxicity

LD50 Intraperitoneal - rat - 1,9 mg/kg

LD50 Intravenous - rat - 1,01 mg/kg

Remarks: Diarrhoea Kidney, Ureter, Bladder:Urine volume increased. Blood:Normocytic anemia.

LD50 Intravenous - mouse - 1,7 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/eye irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

In vitro tests showed mutagenic effects

Genotoxicity in vitro - Human - leukocyte

Cytogenetic analysis

Genotoxicity in vitro - Human - lymphocyte

Micronucleus test

Genotoxicity in vitro - Hamster - Embryo

Morphological transformation.

Genotoxicity in vivo - mouse - Oral

Micronucleus test

Genotoxicity in vivo - mouse - Intraperitoneal

Dominant lethal test

Carcinogenicity

This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC,

ACGIH, NTP, or EPA classification.

IARC:

3 - Group 3: Not classifiable as to its carcinogenicity to humans (Vincristine sulphate)

Reproductive toxicity

Laboratory experiments have shown teratogenic effects. Suspected of damaging the unborn child.

Suspected human reproductive toxicant

Reproductive toxicity - rat - Intraperitoneal

Paternal Effects: Testes, epididymis, sperm duct.

Overexposure may cause reproductive disorder(s) based on tests with laboratory animals. Suspected of

damaging fertility.

Developmental Toxicity - mouse - Intraperitoneal

Specific Developmental Abnormalities: Central nervous system. Specific Developmental Abnormalities:

Eye, ear. Specific Developmental Abnormalities: Craniofacial (including nose and tongue).

Specific target organ toxicity - single exposure

no data available

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard

no data available

Potential health effects

Inhalation

Ingestion

Skin

Eyes

May be harmful if inhaled. May cause respiratory tract irritation.

May be fatal if swallowed.

May be harmful if absorbed through skin. May cause skin irritation.

May cause eye irritation.

Signs and Symptoms of Exposure

Effects due to ingestion may include:, peripheral neuropathy, constipation, Alopecia.

Additional Information

RTECS: OH6340000

12.

12.1

12.2

12.3

12.4

12.5

12.6

13.

13.1

14.

14.1

ECOLOGICAL INFORMATION

Toxicity

no data available

Persistence and degradability

no data available

Bioaccumulative potential

no data available

Mobility in soil

no data available

Results of PBT and vPvB assessment

no data available

Other adverse effects

no data available

DISPOSAL CONSIDERATIONS

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material

with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging

Dispose of as unused product.

TRANSPORT INFORMATION

UN number

14.2

ADR/RID: 2811

UN proper shipping name

IMDG: 2811

IATA: 2811

ADR/RID:

IMDG:

TOXIC SOLID, ORGANIC, N.O.S. (Vincristine sulphate)

IATA:

Toxic solid, organic, n.o.s. (Vincristine sulphate)

14.3

Transport hazard class(es)

14.4

14.5

14.6

15.

ADR/RID: 6.1

Packaging group

ADR/RID: II

Environmental hazards

ADR/RID: no

Special precautions for user

no data available

REGULATORY INFORMATION

IMDG: 6.1

IMDG: II

IMDG Marine pollutant: no

IATA: 6.1

IATA: II

IATA: no

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1

15.2

16.

Safety, health and environmental regulations/legislation specific for the substance or mixture

no data available

Chemical Safety Assessment

no data available

OTHER INFORMATION

Further information

The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. Lookchem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.

;