*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MD9100000
CHEMICAL NAME : Granaticin
CAS REGISTRY NUMBER : 19879-06-2
LAST UPDATED : 199512
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C22-H20-O10
MOLECULAR WEIGHT : 444.42
WISWESSER LINE NOTATION : T F5 E6 C6666/RW 2AQ W DV GOV KO NV TOTT&&TTJ BQ L1
PQ RQ S1 WQ
COMPOUND DESCRIPTOR : Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* Antibiotic WR 141
* Granaticin A
* Granatomycin C
* Litmomycin
* WR 141
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year:
17,63,1969
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 1,135,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GEXXA8 German (East) Patent Document. (U.S. Patent and Trademark Office,
Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #147115
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds.,
Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,823,1967
** MUTATION DATA **
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 600 nmol/L
REFERENCE :
ZBPHA6 Zentralblatt fuer Bakteriologie, Parasitenkunde,
Infektionskrankheiten und Hygiene, Abteilung I: Medizinisch-Hygienische
Bakteriologie, Virusforschung und Parasitologie, Originale. (Stuttgart, Fed.
Rep. Ger.) V.31-216, 1902-71. For publisher information, see ZMMPAO.
Volume(issue)/page/year: 212,259,1969
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 600 nmol/L
REFERENCE :
ZBPHA6 Zentralblatt fuer Bakteriologie, Parasitenkunde,
Infektionskrankheiten und Hygiene, Abteilung I: Medizinisch-Hygienische
Bakteriologie, Virusforschung und Parasitologie, Originale. (Stuttgart, Fed.
Rep. Ger.) V.31-216, 1902-71. For publisher information, see ZMMPAO.
Volume(issue)/page/year: 212,259,1969
*** END OF RECORD ***
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