information Related products Suppliers

Sodium iodide (Na125I)(8CI,9CI)

MATERIAL SAFETY DATA SHEET
(Effective Date: April 2003)

SODIUM IODIDE I-123 CAPSULES
FOR ORAL ADMINISTRATION

1. PRODUCT IDENTIFICATION

Chemical Formula: Na123I
Product Code: 2031, 2032

Formula CAS No.: Not applicable to mixtures. Molecular Weight: 146

Hazardous Ingredients: CAS#24359-64-6 Radioactive Iodine

2. PHYSICAL DATA

100 ??Ci/capsule at time of calibration;
Appearance: Orange, gelatin capsules. Radioactivity:
200 ??Ci/capsule at time of calibration.

Concentration: Approximately 91??Ci/g. Specific Activity: 213 mCi/??g of I-123 at time of calibration.

Odor: Odorless. S olubility: Dissolves in water.

Half-Life: 13.2 hrs. Boiling Point: Not applicable.

Melting Point: Not applicable. Vapor Pressure (mm Hg): Not applicable.

Evaporation Rate : Not applicable. Vapor Density (Air=1): Not applicable.

3. FIRE AND EXPLOSION HAZARD DATA

Fire: Substance is non-flammable.

Explosion: Not considered an explosion hazard.

Fire Extinguishing Media: Use water spray, dry chemical, Co2 or foam as appropriate for the burning material.

Special Information: In the event of a fire, wear full protective clothing and a NIOSH approved self-contained breathing apparatus.
SODIUM IODIDE I-123 CAPSULES
FOR ORAL ADMINISTRATION

4. HEALTH HAZARD DATA

A. Effects of Overexposure

Inhalation: May cause asymptomatic uptake by thyroid gland. Eye Contact: May cause mechanical irritation.

Ingestion: May cause asymptomatic uptake by thyroid gland. Skin Contact: Not considered an acute health hazard.

Chronic Exposure: Data on biological effects of Ionizing Radiation are based on exposures much higher than those permitted
occupationally. No effects are expected from exposures received as a result of normal use.

Aggravation of Pre-existing Conditions: May cause allergic reaction in individuals sensitive to iodine.

B. First Aid Procedures

Inhalation: Move to fresh air and notify physician or Radiation Safety Officer immediately.

Ingestion: Notify Radiation Safety Officer immediately. Assess and document the amount of activity ingested.

Skin Exposure: Wash thoroughly with soap and water or other approved decontamination media. Notify Radiation Safety Officer.

Eye Exposure: Rinse eyes thoroughly with water for a minimum of 15 minutes. Notify Radiation Safety Officer immediately.

C. Toxicity Data

Scientific studies have indicated that large exposures to ionizing radiation can result in an increased probability of long-
term biological effects such as cancer and birth defects. Although these effects have been difficult to demonstrate at low
levels of exposure, efforts should be made to keep exposures as low as reasonably achievable.

5. REACTIVITY DATA

Stability: Material is stable.

Hazardous Decomposition Products: Thermal decomposition may release radioactive Iodine.

Hazardous Polymerization: Will not occur.

Incompatibilities: No information found.
SODIUM IODIDE I-123 CAPSULES
FOR ORAL ADMINISTRATION

6. SPILL OR LEAK PROCEDURES

Radiopharmaceuticals must be handled with care and appropriate safety measures should be used to minimize
exposure to personnel. Radiopharmaceuticals should be used only by physicians who are qualified by training and
experience in safe use and handling of radionuclides, and where experience and training have been approved by the
appropriate regulatory agency authorized to license the use of radionuclides.

7. OCCUPATIONAL PROTECTION INFORMATION

Occupational: 3 x 10-6 ??Ci/cc of air; Nonoccupational: 2 x 10-8 ??Ci/cc of air.
Airborne Exposure Limits:

Personal Respirators: (NIOSH Approved): Not required under normal conditions.

Skin Protection: Disposable rubber, plastic or latex gloves; lab coat. Eye Protection: Safety goggles or safety glasses.

Ventilation System: Use local exhaust.

Precautions: Practice good housekeeping and personal hygiene to preclude the possibility of contaminating work surfaces, equipment and
skin. Avoid inhaling dust or mist; do not pipette solutions by mouth. No smoking, eating, or drinking where radioactive materials are
handled or stored.

8. SPECIAL PRECAUTIONS

Any cleanup of spilled radioactive material should be conducted under the direction of site radiation safety personnel.
Any packages received with leaking internal components should be reported to Amersham Health Technical
Services at 1-800-832-4633. Any packages delivered in a damaged condition should be reported to Amersham Health
Environmental Regulatory Affairs at 847-398-8400.

CALIFORNIA PROPOSITION 65 INFORMATION

The State of California requires that customers and employees are provided with warnings about reproductive and
carcinogenic hazards associated with substances sold in California. Radioactive materials are suspected to cause
reproductive toxicity. Under Proposition 65, the following warning applies:
WARNING: This product contains a substance known to the State of California to cause reproductive toxicity.

MATERIAL SAFETY DATA SHEET STANDARD FORM DISCLAIME
The above information is based upon data available to Amersham Health and is believed to be correct, but
does not intend to be all inclusive and shall be used only as a guide. Since the information contained herein may be
applied under conditions beyond the control of Amersham Health, no responsibility is assumed for the
results of its use.

Amersham Health
3350 North Ridge Avenue
Arlington Heights, IL 60004
(847) 398-8400

;