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Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-11(1H)-one,2,3,6a,9a-tetrahydro-1-hydroxy-4-methoxy-, (1S,6aR,9aS)-

MSDS	:	Cyclopenta(c)furo(3',2'4,5)furo(2,3-h)(1)benzopyran- 11(1H)-one, 2,3,6a,9a-tetrahydro- 1-hydroxy-4-methoxy-
CAS	:	29611-03-8
SYNONYMS	:	* AFL * Aflatoxicol * Aflatoxicol natural epimer * Aflatoxin Ro

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[ Cyclopenta(c)furo(3',2'4,5)furo(2,3-h)(1)benzopyran-11(1H)-one, 2,3,6a,9a-tetrahydro-1-hydroxy-4-methoxy- 29611-03-8 ]

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GY1934000
CHEMICAL NAME           : Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-
                          11(1H)-one, 2,3,6a,9a-tetrahydro-
                          1-hydroxy-4-methoxy-
CAS REGISTRY NUMBER     : 29611-03-8
LAST UPDATED            : 199410
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C17-H14-O6
MOLECULAR WEIGHT        : 314.31
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * AFL
   * Aflatoxicol
   * Aflatoxicol natural epimer
   * Aflatoxin Ro
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1092 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 66,1159,1981
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 25 ng/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 73,2241,1976
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 171,79,1986

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human
   fibroblast

 
                            *** END OF RECORD ***

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