*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CE1050000
CHEMICAL NAME : 6a-alpha-Aporphin-11-ol,
10-methoxy-1,2-(methylenedioxy)-
CAS REGISTRY NUMBER : 298-45-3
LAST UPDATED : 199803
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C19-H19-N-O4
MOLECULAR WEIGHT : 325.39
WISWESSER LINE NOTATION : T D56 J666 1A T EO GO RN FH&&&TTJ KQ LO1 R1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Bulbocapnine
* d-Bulbocapnine
* (S)-(+)-Bulbocapnine
* Bulbokaprin
* 4-Hydroxy-3-methoxy-5,6-methylenedioxy-aporphin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 145 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
spasmolytic)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 155,69,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 195 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 56,85,1936
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 79 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#12068
*** END OF RECORD ***
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