*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AY4025000
CHEMICAL NAME : Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,
monohydrochloride, L-
CAS REGISTRY NUMBER : 3223-07-2
LAST UPDATED : 199706
DATA ITEMS CITED : 4
MOLECULAR FORMULA : C13-H18-Cl2-N2-O2.Cl-H
MOLECULAR WEIGHT : 341.69
WISWESSER LINE NOTATION : QVYZ1R DN2G2G &GH -L
COMPOUND DESCRIPTOR : Tumorigen
Human
SYNONYMS/TRADE NAMES :
* L-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride
* Alanine nitrogen mustard hydrochloride
* L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine monohydrochloride
* Melphalan hydrochloride
* NSC-8806
* L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride
* Phenylalanine mustard hydrochloride
* L-Phenylalanine mustard hydrochloride
* L-Sarcolysine hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 1200 ug/kg/5D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59,
1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
57,369,1973
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 430 ug/kg
TOXIC EFFECTS :
Blood - leukopenia
Blood - thrombocytopenia
Blood - other changes
REFERENCE :
CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5,
1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
2,201,1965
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 430 ug/kg
TOXIC EFFECTS :
Blood - leukopenia
Blood - agranulocytosis
Blood - other changes
REFERENCE :
CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5,
1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
2,201,1965
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1300 ug/kg/4W
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
36,915,1966
*** END OF RECORD ***
|