*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : ES6550000
CHEMICAL NAME : Butyric acid,
2-amino-4-(p-(bis(2-chloroethyl)amino)phenyl)-
CAS REGISTRY NUMBER : 3688-35-5
BEILSTEIN REFERENCE NO. : 3215367
REFERENCE : 4-14-00-01721 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 4
MOLECULAR FORMULA : C14-H20-Cl2-N2-O2
MOLECULAR WEIGHT : 319.26
WISWESSER LINE NOTATION : QVYZ2R DN2G2G
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* 2-Amino-4-(p-(bis(2-chloroethyl)amino)phenyl)butyric acid
* Aminochlorambucil
* alpha-Amino-gamma-(p-dichloroethylamino)phenylbutyric acid
* alpha-Amino-gamma-p-(N,N-di-2-chloroethylamino)phenylbutyric acid
* Benzenebutanoic acid, alpha-amino-4-(bis(2-chloroethyl)amino)-
* CB 1385
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
5,192,1960
TYPE OF TEST : LD10 - Lethal Dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981. For
publisher information, see EJCODS. Volume(issue)/page/year: 10,667,1974
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 10 mmol/L
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
Volume(issue)/page/year: 160,228,1969
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
*** END OF RECORD ***
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