*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EJ3500500
CHEMICAL NAME : Butanamide,
N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)prop
oxy)phenyl)-, (+-)-
CAS REGISTRY NUMBER : 37517-30-9
BEILSTEIN REFERENCE NO. : 2162244
LAST UPDATED : 199612
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C18-H28-N2-O4
MOLECULAR WEIGHT : 336.48
WISWESSER LINE NOTATION : 3VMR CV1 DO1YQ1MY1&1
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Acebutolol
* (+-)-Acebutolol
* dl-Acebutolol
* 1-(2-Acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane
* 3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide
* (+-)-N-(3-Acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)but
anamide
* 5'-Butyramido-2'-(2-hydroxy-3-isopropylaminopropoxy)acetophenone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 152 mg/kg
TOXIC EFFECTS :
Cardiac - change in conduction velocity
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year:
20,69,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 137 mg/kg/24D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
111,533,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 109 mg/kg/22D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
111,533,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku,
Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952-
Volume(issue)/page/year: 42,82,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 75200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPMDAD Nouvelle Presse Medicale. (Paris, France) V.1-11, 1972-82.
Volume(issue)/page/year: 7,3258,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 4 mg/kg
TOXIC EFFECTS :
Cardiac - change in rate
Vascular - BP lowering not characterized in autonomic section
Kidney, Ureter, Bladder - changes in blood vessels or in circulation of
kidney
REFERENCE :
MASODV Masui to Sosei. Anesthesia and Resuscitation. (Hiroshima Masui
Igakkai, Hiroshima Daigaku Igakubu Masuigaku Kyoshitsu, 1-2-3 Kasumi,
Minami-ku, Hiroshima, Hiroshima, Japan) V.6- 1970-
Volume(issue)/page/year: 16,13,1980
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 120 mg/kg
SEX/DURATION : female 34-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc.,
79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
4(Suppl 1),109,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE : 1080 mg/kg
SEX/DURATION : female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
283,1077,1981
*** END OF RECORD ***
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