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1-Propanol,3,3',3''-phosphinidynetris-

Material Safety Data Sheet
Novagen
Customer Number
Order Number

Product and Company Identification
1.
Manufactured by EMD Biosciences, Inc.
Supplier 71186
Catalog #
441 Charmany Drive
In Case of Call Chemtrec?
Madison, WI 53719
Emergency (800)424-9300 (within U.S.A.)
(608)238-6110
(703)527-3887 (outside U.S.A.)
(800)207-0144
FAX: (608)238-1388

P.O. Box 12087
La Jolla, CA 92039-2087
(858)450-5558
(800)854-3417
FAX: (858)453-3552

YeastBuster?? Protein Extraction Reagent
Product name

Composition and Information on Ingredients
2.
Ingredient Name CAS No. Product No. EU Symbol R-Phrases
Ethylene Glycol 107-21-1 RC7170 Xn R22
ASB-16 RC8740 Xi R36/37/38
Lithium Chloride 7447-41-8 RC8750 Xn R22, R36/38
Tris(hydroxypropyl)phosphine 4706-17-6 RC8760 T R23/24/25, R35
Note: See section 8 for occupational exposure limits and section 11 for LC50/LD50 information.

Hazards Identification
3.
RC7170 CAUTION! MAY
Primary Hazards and Critical :
Effects BE HARMFUL IF SWALLOWED.
Do not ingest. Wash thoroughly after handling.
RC8740 CAUTION! MAY
CAUSE RESPIRATORY TRACT, EYE AND SKIN IRRITATION.
Avoid contact with eyes, skin and clothing. Avoid breathing dust. Keep container closed. Use with
adequate ventilation. Wash thoroughly after handling.
RC8750 CAUTION! MAY
BE HARMFUL IF SWALLOWED.
MAY CAUSE EYE AND SKIN IRRITATION.
MAY CAUSE DAMAGE TO THE FOLLOWING ORGANS: GASTROINTESTINAL TRACT.
Avoid contact with eyes, skin and clothing. Do not ingest. Wash thoroughly after handling.
RC8760 DANGER!
CAUSES RESPIRATORY TRACT, EYE AND SKIN BURNS.
HARMFUL IF INHALED, ABSORBED THROUGH SKIN OR SWALLOWED.
MAY CAUSE DAMAGE TO THE FOLLOWING ORGANS: LUNGS, GASTROINTESTINAL
TRACT, RESPIRATORY TRACT, SKIN, HEAD.
Do not get in eyes, on skin or on clothing. Avoid contact with eyes, skin and clothing. Do not
ingest. Do not breathe dust. Keep container closed. Use only with adequate ventilation. Wash
thoroughly after handling.
Physical/Chemical hazards : Not applicable.

RC7170 Harmful if swallowed.
Human Health Hazards :
RC8740 Irritating to eyes, respiratory system and skin.
RC8750 Harmful if swallowed.
Irritating to eyes and skin.
RC8760 Toxic by inhalation, in contact with skin and if swallowed.
Causes severe burns.
Not applicable.
Environmental Hazards :
Catalog # 71186

First Aid Measures
4.
RC7170, RC8740, If inhaled, remove to fresh air. If not breathing, give artificial respiration. If
Inhalation :
RC8750 breathing is difficult, give oxygen. Get medical attention.
RC8760 If inhaled, remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical attention immediately.
RC7170, RC8740, Do NOT induce vomiting unless directed to do so by medical personnel. Never give
Ingestion :
RC8750 anything by mouth to an unconscious person. If large quantities of this material are
swallowed, call a physician immediately.
RC8760 If swallowed, do not induce vomiting unless directed to do so by medical personnel.
Never give anything by mouth to an unconscious person. Get medical attention
immediately.
RC7170 Wash with soap and water. Get medical attention if irritation develops.
Skin Contact :
RC8740, RC8750 In case of contact, immediately flush skin with plenty of water. Remove
contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean
shoes before reuse. Get medical attention.
RC8760 In case of contact, immediately flush skin with plenty of water for at least 15 minutes
while removing contaminated clothing and shoes. Wash clothing before reuse.
Thoroughly clean shoes before reuse. Get medical attention immediately.
RC7170, RC8740, In case of contact, immediately flush eyes with plenty of water for at least 15
Eye Contact :
RC8750 minutes. Get medical attention.
RC8760 In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention immediately.
Not available.
Notes to Medical Doctor :

5. Fire-Fighting Measures
Use foam or all purpose dry chemicals to extinguish.
Extinguishing Media :
Fire fighters should wear positive pressure self-contained breathing apparatus (SCBA) and full turnout gear.
Fire-Fighting Procedures :
Not applicable.
Fire/Explosion Hazards :
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...),
Hazardous Decomposition :
halogenated compounds, phosphates, hydrogen chloride. Some metallic oxides.
Products

Accidental Release Measures
6.
Immediately contact emergency personnel. Keep unnecessary personnel away. Use suitable protective
Personal Precautions :
equipment (Section 8). Follow all fire fighting procedures (Section 5).
If emergency personnel are unavailable, contain spilled material. For small spills add absorbent (soil may be
Environmental Precautions :
used in the absence of other suitable materials) scoop up material and place in a sealed, liquid-proof container
and Clean-up Methods
for disposal. For large spills dike spilled material or otherwise contain material to ensure runoff does not reach a
waterway. Place spilled material in an appropriate container for disposal. Minimize contact of spilled material
with soils to prevent runoff to surface waterways.
Note: See section 1 for emergency contact information and section 13 for waste disposal.

Handling and Storage
7.
RC7170 Do not ingest. Wash thoroughly after handling.
Handling :
RC8740 Avoid contact with eyes, skin and clothing. Avoid breathing dust. Keep container closed.
Use with adequate ventilation. Wash thoroughly after handling.
RC8750 Avoid contact with eyes, skin and clothing. Do not ingest. Wash thoroughly after handling.
RC8760 Do not get in eyes, on skin or on clothing. Avoid contact with eyes, skin and clothing. Do
not ingest. Do not breathe dust. Keep container closed. Use only with adequate
ventilation. Wash thoroughly after handling.
Keep container tightly closed. Keep container in a cool, well-ventilated area.
Storage :
Use original container.
Packaging Materials :

Exposure Controls and Personal Protection
8.
Occupational Exposure Limits
Ingredient Name Occupational Exposure Limits
RC7170 Not available.
RC8740 Not available.
RC8750 Not available.
RC8760 Not available.
RC7170, RC8740, No special containment is required. Local exhaust ventilation should be provided.
Engineering Controls :
RC8750
RC8760 Open handling is not permitted. All handling must be performed in a glove box or other
totally enclosed system.
Personal Protective Equipment
Catalog # 71186

RC7170 Use appropriate respiratory protection if there is the potential to exceed the exposure
Respiratory System :
limit(s).
RC8740, RC8750 Use an approved, properly fitted, HEPA filter cartridge respirator, or a respirator of greater
protection if there is the potential to exceed the exposure limit(s).
RC8760 Use an approved, properly fitted, powered-air purifying respirator or respirator of equivalent
or greater protection.
RC7170, RC8740, Work uniform or laboratory coat.
Skin and Body :
RC8750
RC8760 Disposable outer garments, or impervious garments of equal or greater protection.
RC7170 Use chemical resistant, impervious gloves.
Hands :
RC8740, RC8750 Use latex gloves. Additional body garments should be used based upon the task
being performed (e.g., sleevelets, apron, gauntlets, disposable suits).
RC8760 Use chemical resistant, impervious gloves. Additional body garments should be
used based upon the task being performed (e.g., sleevelets, apron, gauntlets,
disposable suits) to avoid exposed skin surfaces. Appropriate techniques should
be used to remove potentially contaminated clothing.
RC7170 Safety glasses. Goggles, face shield, or other full-face protection if potential exists for
Eyes :
direct exposure to aerosols or splashes.
RC8740, RC8750, Safety glasses. Goggles, face shield, or other full-face protection if potential exists for
RC8760 direct exposure to dust.

Physical and Chemical Properties
9.
Kit Components
100 ml kit
71186: 1 x 100 ml YeastBusterTM Protein Extraction Reagent, containing Ethylene Glycol (RC7170), ASB-16 (RC8740) and Lithium Chloride (RC8750)
71190: 1 x 1 ml 100X THP Solution (RC8760)

500 ml kit
71186: 1 x 500 ml YeastBusterTM Protein Extraction Reagent, containing Ethylene Glycol (RC7170), ASB-16 (RC8740) and Lithium Chloride (RC8750)
71190: 1 x 5 ml 100X THP Solution (RC8760)

Flash Point
Not available.

10. Stability and Reactivity
RC7170, RC8740, RC8750, RC8760 The product is stable.
Stability :
RC8750 Reactive with oxidizing agents, acids.
Conditions and Materials to :
Avoid
RC8750 These products are halogenated compounds, hydrogen chloride.
Hazardous Decomposition :
Products

11. Toxicological Information
Toxicity Data
Test Result Route Species
Ingredient Name
RC7170 LD50 4700 mg/kg Oral Rat
LD50 5500 mg/kg Oral Mouse
LD50 6610 mg/kg Oral Guinea pig
LD50 9530 mg/kg Dermal Rabbit
LDLo 786 mg/kg Oral Human
RC8740 Not available. Not available. Not available. Not available.
RC8750 LD50 526 mg/kg Oral Rat
LD50 800 mg/kg Oral Rabbit
LD50 422 mg/kg Oral Birds.
RC8760 Not available. Not available. Not available. Not available.

Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Routes of Entry :

Acute Effects
RC8740 Moderately irritating to the respiratory system.
Inhalation :
RC8760 Corrosive to the respiratory system. Toxic by inhalation.
RC7170, RC8750 Harmful if swallowed.
Ingestion : RC8760 Toxic if swallowed.

RC7170 Practically non-toxic in contact with skin.
Skin Contact :
RC8740, RC8750 Moderately irritating to the skin.
RC8760 Corrosive to the skin. Toxic in contact with skin.
RC8740, RC8750 Moderately irritating to the eyes.
Eye Contact : RC8760 Corrosive to the eyes.
Catalog # 71186

Chronic Effects
: RC8760 Adverse symptoms may include: respiratory tract irritation inflammation chemical
Adverse Effects
pneumonitis pulmonary edema coughing wheezing - breathing difficulties headache
:
nausea/vomiting.
RC8750 May cause damage to the following organs: gastrointestinal tract.
Target Organs
RC8760 May cause damage to the following organs: lungs, gastrointestinal tract, upper respiratory
:
tract, skin, head.
Not available.
Carcinogenic Effects
Not available.
Mutagenic Effects :
Developmental and Not available.
:
Teratogenic Effects
Not available.
Reproductive Effects :

RC7170, RC8740, Repeated or prolonged exposure is not known to aggravate medical condition.
Other Information :
RC8750
RC8760 Repeated exposure of the eyes to a low level of dust can produce eye irritation. Repeated
skin exposure can produce local skin destruction, or dermatitis. Repeated inhalation of
dust can produce varying degree of respiratory irritation or lung damage. Repeated
exposure to a highly toxic material may produce general deterioration of health by an
accumulation in one or many human organs.

12. Ecological Information
Ecotoxicity Data
Ingredient Name Species Period Result
RC7170 Not available. Not available. Not available.
RC8740 Not available. Not available. Not available.
RC8750 Not available. Not available. Not available.
RC8760 Not available. Not available. Not available.

13. Disposal Consideration
Waste Handling and Disposal : Waste must be disposed of in accordance with federal, state and local environmental control regulations.

14. Transport Information
Air
Not controlled under IATA.
IATA-DGR Class :
Packing Group

15. Regulatory Information
EU Regulations
T
Hazard Symbol(s) :
Risk Phrases R23/24/25- Toxic by inhalation, in contact with skin and if swallowed. R35- Causes severe burns. R36/37/38-
:
Irritating to eyes, respiratory system and skin.
S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39-
Safety Phrases :
Wear suitable protective clothing, gloves and eye/face protection. S45- In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
US Regulations
CLASS: Toxic.
Haz-Com Standard :
CLASS: Target organ effects.
CLASS: Corrosive material

Not available.
EPA :
Not available.
State :

Canadian Regulations
CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
:
WHMIS
CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
CLASS E: Corrosive liquid.

No products were found.
CEPA :
Provincial No products were found.
:
Catalog # 71186

16. Other Information
Validated by jcw on 11/17/2003.
: 1.0
Version
Date of Printing : 11/21/2003.
Notice to Reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its subsidiaries assumes any
liability whatsoever for the accuracy or completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with
caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist. **This product is intended for research
use only.**

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