*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KE2625000
CHEMICAL NAME : Ergoline-8-beta-carboxamide,
2-bromo-9,10-didehydro-N,N-diethyl-6-methyl-
CAS REGISTRY NUMBER : 478-84-2
LAST UPDATED : 199106
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C20-H26-Br-N3-O
MOLECULAR WEIGHT : 404.40
WISWESSER LINE NOTATION : T C6656 1A P GN LN CUTT&&J EVN2&2 G1 KE L1
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* BOL
* BOL-148
* D-2-Brom-diethylamide of lysergic acid
* Brom LSD
* 2-Bromo-9,10-didehydro-N,N-diethyl-6-methylergoline-8-beta-carboxamide
* 2-Bromo-D-lysergic acid diethylamide
* 2-Brom-D-lysergic acid diethylamine
* Bromlysergamide
* Bromolysergide
* 9,10-Didehydro-N,N-diethyl-2-bromo-6-methylergoline-8-beta-carboxamide
* USAF SZ-1
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 75 ug/kg
TOXIC EFFECTS :
Vascular - regional or general arteriolar or venous dilation
REFERENCE :
PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For
publisher information, see PSCHDL. Volume(issue)/page/year: 1,20,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 6 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
Volume(issue)/page/year: 66,668,1957
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - hamster
DOSE : 2 ug/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
158,265,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - hamster
DOSE : 2 ug/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - homeostasis
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
158,265,1967
*** END OF RECORD ***
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