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Section 1 - Chemical Product and Company Identification |
MSDS Name: Acetohydroxamic acid, 98%
Catalog Numbers:
AC170130000, AC170130050, AC170130100, AC170130250
Synonyms:
AHA; N-Hydroxyacetamide; Acetic acid, oxime; N-Acetylhydroxylamine;
Lithostat.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 546-88-3 |
Acetohydroxamic acid |
98 | 208-913-8 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: white to light yellow solid.
Caution! May cause harm to the unborn child. May
cause eye, skin, and respiratory tract irritation. Hygroscopic
(absorbs moisture from the air).
Target Organs: Reproductive system.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
Acetohydroxamic acid is used to prevent formation of kidney stones.
It is relatively nontoxic by the oral exposure route. Reported
adverse effects include headache, nausea, loss of appetite, tremors,
confusion, depression, anxiety, reduction of red blood
cells/hemoglobin/hematocrit, hemolytic anemia, increased risk of
blood clots, pulmonary embolism, superficial and deep vein
thromboses, skin rash, and hair loss.
Inhalation:
May cause respiratory tract irritation.
Chronic:
Acetohydroxamic acid was teratogenic in rats and dogs, inducing CNS,
heart, limb, and tail defects. It can induce limb bud cell death in
rabbits. The fetus is more sensitive than the mother.
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Section 4 - First Aid Measures
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Eyes:
In case of contact, immediately flush eyes with plenty of water for a
t least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. This material in sufficient quantity and reduced
particle size is capable of creating a dust explosion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Flash Point: Not applicable.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 1; Flammability: 1; Instability: 0
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Clean up spills immediately, observing precautions in the
Protective Equipment section. Provide ventilation.
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Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Wash hands before eating. Remove
contaminated clothing and wash before reuse. Use with adequate
ventilation. Avoid contact with eyes, skin, and clothing. Avoid
breathing dust.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Acetohydroxamic acid
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none listed
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none listed
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none listed
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OSHA Vacated PELs:
Acetohydroxamic acid:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Solid
Appearance: white to light yellow
Odor: Faint, acetic acid-like odor.
pH: 9.39 (aq soln)
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:86 - 92 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:Not available.
Molecular Formula:C2H5NO2
Molecular Weight:75.06
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 546-88-3:
AK8157000
LD50/LC50:
Not available.
Oral LD50 rat: 4.8 g/kg.
Carcinogenicity:
CAS# 546-88-3:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No data available.
Teratogenicity:
See actual entry in RTECS for complete information.
Reproductive Effects:
No data available.
Mutagenicity:
See actual entry in RTECS for complete information.
Neurotoxicity:
No data available.
Other Studies:
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Section 12 - Ecological Information
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No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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US DOT |
Canada TDG |
| Shipping Name: |
Not regulated as a hazardous material |
No information available. |
| Hazard Class: |
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| UN Number: |
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| Packing Group: |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 546-88-3 is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 546-88-3 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
WARNING: This product contains Acetohydroxamic acid, a chemical known
to the state of California to cause developmental reproductive
toxicity.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 61 May cause harm to the unborn child.
Safety Phrases:
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 53 Avoid exposure - obtain special instructions before use.
WGK (Water Danger/Protection)
CAS# 546-88-3: No information available.
Canada - DSL/NDSL
CAS# 546-88-3 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D2A.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
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Section 16 - Additional Information
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MSDS Creation Date: 9/02/1997
Revision #5 Date: 3/22/2006
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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