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Isoniazid

1 - Product and Company Information

Product Name ISONICOTINIC ACID HYDRAZIDE FREE BASE
Product Number I3377
2 - Composition/Information on Ingredients

Product Name CAS # EC no Annex I
Index Number
ISO-NICOTINIC ACID HYDRAZIDE 54-85-3 200-214-6 None

Formula C6H7N3O
Molecular Weight 137.14 AMU
Synonyms Andrazide * Antimicina * Antituberkulosum *
Armazide * Atcotibine * Azuren * BP 5015 * Cedin
* Cemidon * Chemiazid * Chemidon * Cotinazin *
Defonin * Dibutin * Diforin * Dinacrin * Ditubin
* Ebidene * Eralon * Ertuban * Eutizon * Evalon
* Fimalene * FSR 3 * GInk * HIA * Hidranizil *
Hidrasonil * Hidrulta * Hidrun * Hycozid *
Hydrazid * 4-(Hydrazinocarbonyl)pyridine *
Hyozid * Hyzyd * I.A.I. * Ido-tebin * Idrazide
dell'acido isonicotinico (Italian) * Idrazil *
IN-73 * INAH * INH * Inizid * Iscotin * Isidrina
* Ismazide * Isobicina * Isocid * Isocidene *
Isocotin * Isolyn * Isonerit * Isonex *
Isoniazid * Isoniazide * Isonicazide * Isonicid
* Isonico * Isonicotan * Isonicotil *
Isonicotinhydrazid * Isonicotinoyl hydrazide *
Isonicotinoylhydrazine *
Isonicotinsaeurehydrazid (German) * Isonicotinyl
hydrazide * Isonide * Isonidrin * Isonikazid *
Isonilex * Isonin * Isonindon * Isonirit *
Isoniton * Isonizide * Isotebe * Isotebezid *
Isotinyl * Isozide * Isozyd * L 1945 * Laniazid
* Mybasan * Neoteben * Neo-tizide * Neoxin *

3 - Hazards Identification

SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to skin.
4 - First Aid Measures

AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.

AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.

AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.

AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.

5 - Fire Fighting Measures

EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.

SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.

SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

6 - Accidental Release Measures

PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.

PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.

METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.

7 - Handling and Storage

HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.

STORAGE
Conditions of Storage: Keep tightly closed.

8 - Exposure Controls / Personal Protection

ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.

SIGMA - I3377 www.-aldrich.com GENERAL HYGIENE MEASURES
Wash thoroughly after handling.

PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.

9 - Physical and Chemical Properties

Appearance Physical State: Solid
Color: White
Form: Powder

Property Value At Temperature or Pressure

pH 5.5 - 6.5 Concentration: 10 g/l
BP/BP Range N/A
MP/MP Range 170 ??C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient Log Kow: -0.7
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Other Solvents: MEK,ACETONE, CHLOROFORM

10 - Stability and Reactivity

STABILITY
Materials to Avoid: Strong oxidizing agents.

HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.

HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

11 - Toxicological Information

RTECS NUMBER: NS1751850

ACUTE TOXICITY

LDLO

SIGMA - I3377 www.-aldrich.com Oral
Man
523 mg/kg
17W-I
Remarks: Liver:Hepatitis (hepatocellular necrosis), diffuse.
Liver:Hepatitis, fibrous (cirrhosis, post-necrotic scarring).

LDLO
Oral
Human
100 mg/kg
Remarks: Peripheral Nerve and Sensation:Structural change in
nerve or sheath.

LDLO
Oral
Man
116 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Cardiac:Other changes. Lungs, Thorax, or Respiration:Emphysema.

LD50
Oral
Rat
1250 mg/kg

LD50
Intraperitoneal
Rat
335 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia.

LD50
Subcutaneous
Rat
329 MG/KG

LD50
Intravenous
Rat
365 MG/KG

LD50
Intramuscular
Rat
400 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.

LD50
Oral
Mouse
133 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Dyspnea.

LD50
Intraperitoneal
Mouse
100 MG/KG

LD50

SIGMA - I3377 www.-aldrich.com Subcutaneous
Mouse
125 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.

LD50
Intravenous
Mouse
149 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.

LD50
Intramuscular
Mouse
137 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Dyspnea.

LD50
Oral
Dog
50 mg/kg

LD50
Intraperitoneal
Cat
325 MG/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Behavioral:Convulsions or effect on
seizure threshold. Lungs, Thorax, or Respiration:Dyspnea.

LD50
Oral
Rabbit
250 mg/kg

LD50
Intraperitoneal
Rabbit
147 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia.

LD50
Subcutaneous
Rabbit
135 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia.

LD50
Intravenous
Rabbit
94 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.

LD50
Intramuscular
Rabbit
155 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia.

SIGMA - I3377 www.-aldrich.com LD50
Intracerebral
Rabbit
>12 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia.

LD50
Oral
Guinea pig
255 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia.

LD50
Intraperitoneal
Guinea pig
195 MG/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Behavioral:Convulsions or effect on
seizure threshold. Lungs, Thorax, or Respiration:Dyspnea.

LD50
Subcutaneous
Guinea pig
195 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia.

LD50
Intravenous
Guinea pig
220 MG/KG
Remarks: Gastrointestinal:Hypermotility, diarrhea.

LD50
Intramuscular
Guinea pig
255 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia.

IRRITATION DATA

Skin
Rabbit
500 mg
24H
Remarks: Moderate irritation effect

SIGNS AND SYMPTOMS OF EXPOSURE
The chemical, physical, and toxicological properties of this
product have not been thoroughly investigated.

ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.

SIGMA - I3377 www.-aldrich.com TARGET ORGAN INFORMATION
Liver. Nerves. Blood.

CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.

Rat
Route of Application: Oral
Exposure Time: 45W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors. Skin and Appendages: Other: Tumors.

Mouse
Route of Application: Oral
Result: Tumorigenic:Carcinogenic by RTECS criteria. Tumorigenic
Effects: Uterine tumors. Lungs, Thorax, or Respiration:Tumors.

Mouse
Route of Application: Oral
Exposure Time: 84W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs,
Thorax, or Respiration:Tumors.

Mouse
Route of Application: Intraperitoneal
Exposure Time: 8W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Leukemia Blood:Lymphomas including Hodgkin's disease.

Mouse
Route of Application: Subcutaneous
Exposure Time: 18W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors.

Mouse
Route of Application: Unreported
Exposure Time: 39W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Bronchiogenic carcinoma.

Mouse
Route of Application: Oral
Exposure Time: 70W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs,
Thorax, or Respiration:Tumors. Liver:Tumors.

Mouse
Route of Application: Oral
Exposure Time: 30W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors.

Mouse
Route of Application: Oral
Exposure Time: 49W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors. Liver:Tumors.

SIGMA - I3377 www.-aldrich.com Mouse
Route of Application: Oral
Exposure Time: 98W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs,
Thorax, or Respiration:Tumors.

Mouse
Route of Application: Oral
Exposure Time: 19W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors. Nutritional and
Gross Metabolic:Weight loss or decreased weight gain.

Mouse
Route of Application: Subcutaneous
Exposure Time: 21 Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Bronchiogenic carcinoma.
Liver:Tumors.

Mouse
Route of Application: Oral
Exposure Time: 17W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors. Liver:Tumors.

Mouse
Route of Application: Oral
Exposure Time: 4W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors. Liver:Tumors.

Mouse
Route of Application: Oral
Exposure Time: 32W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors.

Mouse
Route of Application: Intraperitoneal
Exposure Time: 32W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors.

IARC CARCINOGEN LIST

Rating: Group 3

CHRONIC EXPOSURE - MUTAGEN

Human
100 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis

Human
300 MMOL/L
Cell Type: HeLa cell
DNA inhibition

Human
10 MMOL/L

SIGMA - I3377 www.-aldrich.com Cell Type: fibroblast
DNA inhibition

Human
10 MMOL/L
Cell Type: lymphocyte
Other mutation test systems

Human
7 MMOL/L
Cell Type: lymphocyte
Cytogenetic analysis

Human
5 GM/L
Cell Type: leukocyte
Cytogenetic analysis

Human
5 MG/L
Cell Type: Bone marrow
Cytogenetic analysis

Rat
90 MG/KG
Cell Type: S. typhimurium
Body fluid assay

Rat
900 MG/KG
Oral
12W
Cytogenetic analysis

Rat
65 MG/KG
Intravenous
Cytogenetic analysis

Rat
150 MG/KG
Cell Type: S. typhimurium
Host-mediated assay

Mouse
100 MG/KG
Intraperitoneal
specific locus test

Mouse
960 UMOL/KG
Intraperitoneal
DNA damage

Mouse
28 MG/KG
Oral
DNA

Mouse
90 MG/KG
Intraperitoneal

SIGMA - I3377 www.-aldrich.com DNA inhibition

Mouse
14667 UG/KG
Intraperitoneal
Other mutation test systems

Mouse
14667 UG/KG
Intraperitoneal
Cytogenetic analysis

Mouse
1 MMOL/L
Cell Type: Ascites tumor
Cytogenetic analysis

Mouse
3200 UMOL/L
24H
Cell Type: mammary gland
Cytogenetic analysis

Mouse
14700 UG/KG
Intraperitoneal
Cytogenetic analysis

Mouse
150 MG/KG
Cell Type: S. typhimurium
Host-mediated assay

Mouse
150 MG/KG
Cell Type: E. coli
Host-mediated assay

Mouse
900 MG/KG
Intraperitoneal
sperm

Hamster
10 MMOL/L
Cell Type: ovary
DNA inhibition

Hamster
10 MG/KG
Oral
2W
Cytogenetic analysis

Hamster
1 GM/L
Cell Type: lung
Cytogenetic analysis

Hamster
3 GM/L
Cell Type: fibroblast

SIGMA - I3377 www.-aldrich.com Cytogenetic analysis

Hamster
1 MMOL/L
Cell Type: ovary
Sister chromatid exchange

Hamster
10 MMOL/L
Cell Type: lung
Sister chromatid exchange

Hamster
150 MG/KG
Cell Type: S. typhimurium
Host-mediated assay

Guinea pig
150 MG/KG
Cell Type: S. typhimurium
Host-mediated assay

CHRONIC EXPOSURE - TERATOGEN

Species: Rat
Dose: 27900 UG/KG
Route of Application: Subcutaneous
Exposure Time: (6-14D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Musculoskeletal
system.

Species: Mouse
Dose: 1848 MG/KG
Route of Application: Oral
Exposure Time: (1-21D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Effects on
Newborn: Delayed effects.

CHRONIC EXPOSURE - REPRODUCTIVE HAZAR
Species: Rat
Dose: 2790 UG/KG
Route of Application: Subcutaneous
Exposure Time: (6-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth).

Species: Mouse
Dose: 160 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-13D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth). Specific Developmental Abnormalities:
Musculoskeletal system.

Species: Rabbit
Dose: 40 MG/KG

SIGMA - I3377 www.-aldrich.com Route of Application: Oral
Exposure Time: (7-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth).

12 - Ecological Information

ECOTOXICOLOGICAL EFFECTS

Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 84.6 mg/l

13 - Disposal Considerations

SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.

14 - Transport Information

RID/AD Non-hazardous for road transport.

IMDG
Non-hazardous for sea transport.

IATA
Non-hazardous for air transport.

15 - Regulatory Information

CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 38
Harmful if swallowed. Irritating to skin.
S-PHRASES: 37
Wear suitable gloves.

SWITZERLAN SWISS POISON CLASS: 3

16 - Other Information

WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited

SIGMA - I3377 www.-aldrich.com paper copies for internal use only.

DISCLAIME For R&D use only. Not for drug, household or other uses.

SIGMA - I3377 www.-aldrich.com
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