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Disulfiram

1.1

IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product identifiers

Product name

Product Number

Brand

Index-No.

CAS-No.

Tetraethylthiuram disulfide

86720

Anonymous

006-079-00-8

97-77-8

1.2

Relevant identified uses of the substance or mixture and uses advised against

Identified uses

Laboratory chemicals, Manufacture of substances

2.1

2.2

HAZARDS IDENTIFICATION

Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]

Acute toxicity, Oral (Category 4)

Specific target organ toxicity - repeated exposure (Category 2)

Skin sensitization (Category 1)

Acute aquatic toxicity (Category 1)

Chronic aquatic toxicity (Category 1)

Classification according to EU Directives 67/548/EEC or 1999/45/EC

Harmful if swallowed. Harmful: danger of serious damage to health by prolonged exposure if swallowed.

May cause sensitization by skin contact. Very toxic to aquatic organisms, may cause long-term adverse

effects in the aquatic environment.

Label elements

Labelling according Regulation (EC) No 1272/2008 [CLP]

Pictogram

Signal word

Hazard statement(s)

H302

H317

H373

H410

Warning

Harmful if swallowed.

May cause an allergic skin reaction.

May cause damage to organs through prolonged or repeated exposure.

Very toxic to aquatic life with long lasting effects.

Precautionary statement(s)

P273

P280

P501

Supplemental Hazard

Avoid release to the environment.

Wear protective gloves.

Dispose of contents/ container to an approved waste disposal plant.

none

Statements

According to European Directive 67/548/EEC as amended.

Hazard symbol(s)

R-phrase(s)

R22

R43

R48/22

R50/53

Harmful if swallowed.

May cause sensitization by skin contact.

Harmful: danger of serious damage to health by prolonged exposure if

swallowed.

Very toxic to aquatic organisms, may cause long-term adverse effects in

the aquatic environment.

S-phrase(s)

S24

S37

S60

S61

Avoid contact with skin.

Wear suitable gloves.

This material and its container must be disposed of as hazardous waste.

Avoid release to the environment. Refer to special instructions/ Safety

data sheets.

2.3

3.1

Other hazards - none

COMPOSITION/INFORMATION ON INGREDIENTS

Substances

Synonyms

Formula

Molecular Weight

Component

Tetraethylthiuramdisulfide

Bis(diethylthiocarbamyl) disulfide

Disulfiram

Bis(diethylthiocarbamoyl) disulfide

C10H20N2S4

296,54 g/mol

Concentration

CAS-No.

EC-No.

Index-No.

97-77-8

202-607-8

006-079-00-8

4.1

FIRST AID MEASURES

Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2

4.3

5.1

5.2

5.3

5.4

6.1

6.2

6.3

6.4

7.1

7.2

7.3

8.1

8.2

Most important symptoms and effects, both acute and delayed

A serious toxic interaction has been observed in rats fed tetraethylthiuram (antabuse, ro-sulfiram) and then

exposed to vapors of 1,2-dibromoethane., May cause nervous system disturbances., Lethargy., Ataxia.,

Seizures., Coma., thyroid enlargement

Indication of any immediate medical attention and special treatment needed

no data available

FIREFIGHTING MEASURES

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides, nitrogen oxides (NOx), Sulphur oxides

Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

Further information

no data available

ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure

adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the

environment must be avoided.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed

containers for disposal.

Reference to other sections

For disposal see section 13.

HANDLING AND STORAGE

Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols.

Provide appropriate exhaust ventilation at places where dust is formed.

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Specific end uses

no data available

EXPOSURE CONTROLS/PERSONAL PROTECTION

Control parameters

Components with workplace control parameters

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and

at the end of workday.

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under

appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique

(without touching glove's outer surface) to avoid skin contact with this product. Dispose of

contaminated gloves after use in accordance with applicable laws and good laboratory practices.

Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and

the standard EN 374 derived from it.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected

according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher

level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.

Use respirators and components tested and approved under appropriate government standards

such as NIOSH (US) or CEN (EU).

9.1

PHYSICAL AND CHEMICAL PROPERTIES

Information on basic physical and chemical properties

Appearance

Odour

Odour Threshold

Melting point/freezing

point

Initial boiling point and

boiling range

Flash point

Evaporation rate

Form: powder

Colour: beige

no data available

Melting point/range: 69 - 71 °C

no data available

Flammability (solid, gas) no data available

Upper/lower

flammability or

explosive limits

Vapour pressure

Vapour density

no data available

m) Relative density

no data available

Water solubility

Partition coefficient: n-

octanol/water

Autoignition

temperature

Decomposition

temperature

Viscosity

Explosive properties

Oxidizing properties

no data available

log Pow: 5

no data available

9.2

Other safety information

no data available

10.

10.1

10.2

10.3

10.4

10.5

10.6

11.

11.1

STABILITY AND REACTIVITY

Reactivity

no data available

Chemical stability

no data available

Possibility of hazardous reactions

no data available

Conditions to avoid

no data available

Incompatible materials

Strong oxidizing agents

Hazardous decomposition products

Other decomposition products - no data available

TOXICOLOGICAL INFORMATION

Information on toxicological effects

Acute toxicity

LDLO Oral - Human - female - 90 mg/kg

Remarks: Behavioral:Coma. Liver:Jaundice, other or unclassified. Kidney, Ureter, Bladder:Changes in

tubules (including acute renal failure, acute tubular necrosis).

LDLO Oral - Human - male - 150 mg/kg

Remarks: Liver:Hepatitis (hepatocellular necrosis), diffuse.

LDLO Oral - Human - 160 mg/kg

Remarks: Behavioral:Coma. Gastrointestinal:Ulceration or bleeding from large intestine. Liver:Hepatitis,

fibrous (cirrhosis, post-necrotic scarring).

LD50 Oral - rabbit - 1.800 mg/kg

Remarks: Peripheral Nerve and Sensation:Flaccid paralysis without anesthesia (usually neuromuscular

blockage). Behavioral:Ataxia. Nutritional and Gross Metabolic:Changes in:Body temperature decrease.

LD50 Oral - mouse - 1.980 mg/kg

LD50 Intraperitoneal - rat - 248 mg/kg

Remarks: Behavioral:Change in motor activity (specific assay). Nutritional and Gross Metabolic:Changes

in:Body temperature decrease.

LD50 Intraperitoneal - mouse - 75 mg/kg

LD50 Subcutaneous - mouse - 2.600 mg/kg

Skin corrosion/irritation

Serious eye damage/eye irritation

Eyes - rabbit - Mild eye irritation

Respiratory or skin sensitization

May cause allergic skin reaction.

Germ cell mutagenicity

Genotoxicity in vitro - Hamster - ovary

Sister chromatid exchange

Genotoxicity in vitro - Hamster - Embryo

Morphological transformation.

Genotoxicity in vitro - Chicken - Embryo

Other mutation test systems

Genotoxicity in vitro - Human - HeLa cell

DNA inhibition

Genotoxicity in vitro - mouse - Embryo

DNA inhibition

Genotoxicity in vitro - mouse - lymphocyte

Genotoxicity in vitro - Chicken - Embryo

DNA inhibition

Genotoxicity in vivo - mouse - Oral

Sister chromatid exchange

Genotoxicity in vivo - rat - Oral

Morphological transformation.

Carcinogenicity

This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC,

ACGIH, NTP, or EPA classification.

IARC:

No component of this product present at levels greater than or equal to 0.1% is identified as

probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

no data available

Specific target organ toxicity - single exposure

no data available

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard

no data available

Potential health effects

Inhalation

Ingestion

Skin

Eyes

May be harmful if inhaled. May cause respiratory tract irritation.

Harmful if swallowed.

May be harmful if absorbed through skin. May cause skin irritation.

Causes eye irritation.

Signs and Symptoms of Exposure

A serious toxic interaction has been observed in rats fed tetraethylthiuram (antabuse, ro-sulfiram) and then

exposed to vapors of 1,2-dibromoethane., May cause nervous system disturbances., Lethargy., Ataxia.,

Seizures., Coma., thyroid enlargement

Additional Information

RTECS: JO1225000

12.

12.1

ECOLOGICAL INFORMATION

Toxicity

Toxicity to fish

Toxicity to daphnia and

other aquatic

invertebrates

Toxicity to algae

LC50 - Poecilia reticulata (guppy) - 0,32 mg/l - 96,0 h

LC50 - Daphnia magna (Water flea) - 0,12 mg/l - 48 h

Growth inhibition EC50 - Chlorella pyrenoidosa - 1,8 mg/l - 96 h

12.2

12.3

12.4

Persistence and degradability

Bioaccumulative potential

no data available

Mobility in soil

no data available

12.5

12.6

13.

13.1

14.

14.1

Results of PBT and vPvB assessment

no data available

Other adverse effects

Very toxic to aquatic life.

DISPOSAL CONSIDERATIONS

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material

with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging

Dispose of as unused product.

TRANSPORT INFORMATION

UN number

14.2

ADR/RID: 3077

UN proper shipping name

IMDG: 3077

IATA: 3077

ADR/RID:

IMDG:

IATA:

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

(Tetraethylthiuramdisulfide)

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

(Tetraethylthiuramdisulfide)

Environmentally hazardous substance, solid, n.o.s. (Tetraethylthiuramdisulfide)

14.3

Transport hazard class(es)

14.4

14.5

14.6

ADR/RID: 9

Packaging group

ADR/RID: III

Environmental hazards

ADR/RID: yes

Special precautions for user

IMDG: 9

IMDG: III

IMDG Marine pollutant: yes

IATA: 9

IATA: III

IATA: yes

Further information

EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination

packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids.

15.

15.1

15.2

16.

REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Safety, health and environmental regulations/legislation specific for the substance or mixture

no data available

Chemical Safety Assessment

no data available

OTHER INFORMATION

Further information

The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. Lookchem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.

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