information Related products Suppliers

Hexanoic acid,6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-,2,5-dioxo-1-pyrrolidinyl ester

Eng

Material Safety Data Sheet
Conforms to 93/112/EC and ISO 11014-1
Responsible Name Pierce Administration
Section 1. Chemical Product and Company Identification
EZ-Link?? NHS-LC-Biotin
Product name
Product No. 0021336 0021336B
Supplier In USA:In Europe: Manufacturer Pierce Biotechnology
Pierce Perbio Science P.O. Box 117
P.O. Box 117
Industriezone III Rockford, IL 61105
Rockford, IL 61105
Industrielaan 27 USA 9320 Erembodegem-Aalst 815.968.0747 or
815.968.0747 or
Belgium 1.800.874.3723
1.800.874.3723
Tel:+32 53 83 44 04
Fax:+32 53 83 76 38
In Case of Emergency CALL CHEMTREC: Print Date 11/11/2002
800.424.9300 Validation Date 11/4/2002
OUTSIDE US:
MSDS# 814
202.483.7616

Synonyms Succinimidyl 6-(biotinamido)hexanoate

Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.

Section 2. Composition, Information on Ingredients
Substance/Preparation : Substance

CAS No. EC Number Symbol R-Phrases
Ingredient Name %
1) EZ-Link NHS-LC-Biotin 72040-63-2 98-100 Not available. Xi R36

Section 3. Hazards Identification
United States Review the most current and approved institutional guideline, protocol, standard operating procedure(s) and MSDS(s)
for the proper handling of institutional materials/equipment associated with the use of this product.
Emergency Overview WARNING!
CAUSES DAMAGE TO THE FOLLOWING ORGANS: EYES.
MAY CAUSE EYE IRRITATION.
Avoid contact with eyes. Wash thoroughly after handling.

Routes of Entry Absorbed through skin. Eye contact. Inhalation. Ingestion.
Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant). Non-hazardous in case of ingestion.
Non-hazardous in case of inhalation. Non-irritant for lungs.
CARCINOGENIC EFFECTS: Not available.
Carcinogenic Effects Data MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
Medical Conditions Aggravated by Repeated or prolonged exposure is not known to aggravate medical condition.
Overexposure:
Overexposure /Signs/Symptoms Not available.

Europe

Classification R36
Physical/chemical hazards Not applicable.
Human health hazards Irritating to eyes.
Environmental hazards Not applicable.

See Toxicological Information (section 11)

Continued on Next EZ-Link?? NHS-LC-Biotin

Section 4. First Aid Measures

Notice to Reader Get immediate medical attention.
Effects and symptoms
Inhalation Non-hazardous in case of inhalation. Non-irritant for lungs.
Ingestion Non-hazardous in case of ingestion.
Skin Contact Slightly hazardous in case of skin contact (irritant). Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Eye Contact Slightly hazardous in case of eye contact (irritant).
Aggravating conditions Repeated or prolonged exposure is not known to aggravate medical condition.

First-Aid Measures
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
attention if symptoms appear.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious
person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a
collar, tie, belt or waistband.
Skin Contact Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Cold water may be used. WARM water MUST be used. Get medical attention.
Notes to Physician Not available.
Protection of first-aiders Not available.

Section 5. Fire Fighting Measures

Flammability of the Product May be combustible at high temperature.
Flash Points Not available.

Fire Hazards in Presence of Various Not available.
Substances

Fire Fighting Media SMALL FIRE: Use DRY chemical powder.
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Protective Clothing (Fire) Be sure to use an approved/certified respirator or equivalent.

Hazardous thermal (de)composition These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...).
products

Section 6. Accidental Release Measures

Personal precautions Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Environmental Precautions and Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the
Clean-up Methods contaminated surface and allow to evacuate through the sanitary system.
Small Spill and Leak Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
water on the contaminated surface and dispose of according to local and regional authority requirements.

Section 7. Handling and Storage

Handling Avoid contact with eyes. Wash thoroughly after handling.

Storage Keep container tightly closed. Keep container in a cool, well-ventilated area.
Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.
Packaging materials
Suitable / Not suitable Use original container.

Continued on Next EZ-Link?? NHS-LC-Biotin

Section 8. Exposure Controls/Personal Protection

Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.

Exposure Limit Values
Ingredient Name Occupational Exposure Limits
United States
1) EZ-Link NHS-LC-Biotin Not available.

Sweden
1) EZ-Link NHS-LC-Biotin Not available.

Denmark
1) EZ-Link NHS-LC-Biotin Not available.

Norway
1) EZ-Link NHS-LC-Biotin Not available.

France
1) EZ-Link NHS-LC-Biotin Not available.

Netherlands
1) EZ-Link NHS-LC-Biotin Not available.

Germany
1) EZ-Link NHS-LC-Biotin Not available.

Personal Protection
Splash goggles.
Eyes
Lab coat.
Body
Gloves.
Hands
Respirator is not needed under normal and intended conditions of use, if exposures are kept below established limits.
Respiratory
Protective Clothing
(Pictograms)

Section 9. Physical and Chemical Properties

Physical State and Solid. (Solid powder.) Odor Not available.
Appearance
Taste Not available.
Molecular Weight 454.54 g/mole
Color White. Off-white. Tan.
Molecular Formula C20H29O6N4S
Melting/Freezing Point 171??C (339.8??F)
Dispersion Properties Not available.

Solubility Very slightly soluble in cold water, hot water.

Continued on Next EZ-Link?? NHS-LC-Biotin

Section 10. Stability and Reactivity
Stability and Reactivity The product is stable.
Conditions to avoid Not available.
Materials to avoid Not available.

Hazardous Polymerization Will not occur.

Hazardous Decomposition These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...).
Products

Section 11. Toxicological Information

Toxicity to Animals LD50: Not available.
LC50: Not available.
Chronic Effects on Humans Causes damage to the following organs: eyes.

Other Toxic Effects on Humans Slightly hazardous in case of eye contact (irritant).
Non-hazardous in case of inhalation. Non-irritant for lungs. Non-sensitizer for lungs.
Special Remarks on Toxicity to Not available.
Animals
Special Remarks on Chronic Not available.
Effects on Humans
Special Remarks on Other Toxic Not available.
Effects on Humans

Section 12. Ecological Information

Mobility Not available.
Persistence/degradability Not available.
Bioaccumulative potential Not available.
Ecotoxicity Not available.
Germany water class VCI WGK: No products were found.

Section 13. Disposal Considerations

Waste Information Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Waste Stream Not available.

Consult your local or regional authorities.

Section 14. Transport Information
Contact the supplier for all information regarding the proper transportation method for this material.

1

Section 15. Regulatory Information

Label Requirements

Continued on Next EZ-Link?? NHS-LC-Biotin

R36- Irritating to eyes.
(Europe)
S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Irritant

HCS Classification Irritating substance.

U.S. Federal Regulations TSCA: No products were found.
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: No products were found.
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found.
SARA 313 toxic chemical notification and release reporting: No products were found.
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean air act (CAA) 112 accidental release prevention: No products were found.
Clean air act (CAA) 112 regulated flammable substances: No products were found.
Clean air act (CAA) 112 regulated toxic substances: No products were found.

WHMIS (Canada) Not controlled under WHMIS (Canada).

No products were found.

International Regulations

EINECS Not available.

DSCL (EEC) R36- Irritating to eyes.
International Lists VCI WGK: No products were found.
State Regulations No products were found.
California prop. 65: No products were found.

Section 16. Other Information

Hazardous Material National Fire Protection
* 1
Health
Fire Hazard
0
Information System Association (U.S.A.)
0
Fire Hazard
(U.S.A.)
1 0
Health Reactivity
0
Reactivity
Specific Hazard
E
Personal Protection

References Not available.
History of Document Changes Any information changes since last document version are marked with a triangle symbol.
Full text of R-Phrases Irritating to eyes.
referenced under headings 2 and 3:

Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.

Continued on Next EZ-Link?? NHS-LC-Biotin
Date of Previous Issue No Previous
Validated by Pierce Administration on 11/4/2002. Verified by Pierce Administration.
Validation
Printed 11/11/2002. Version 0.01
Notice to Reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its subsidiaries assumes any
liability whatsoever for the accuracy or completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution.
Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.

;